ID   DRS7C_XENTR             Reviewed;         311 AA.
AC   A9UM79;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7C;
DE            EC=1.1.-.-;
DE   AltName: Full=Short-chain dehydrogenase/reductase family 32C member 2 {ECO:0000250|UniProtKB:A6NNS2};
DE   Flags: Precursor;
GN   Name=dhrs7c; Synonyms=sdr32c2 {ECO:0000250|UniProtKB:A6NNS2};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC157553; AAI57554.1; -; mRNA.
DR   RefSeq; NP_001107423.1; NM_001113951.1.
DR   AlphaFoldDB; A9UM79; -.
DR   SMR; A9UM79; -.
DR   STRING; 8364.ENSXETP00000026781; -.
DR   PaxDb; A9UM79; -.
DR   Ensembl; ENSXETT00000026781; ENSXETP00000026781; ENSXETG00000012255.
DR   GeneID; 100135266; -.
DR   KEGG; xtr:100135266; -.
DR   CTD; 201140; -.
DR   Xenbase; XB-GENE-5956201; dhrs7c.
DR   eggNOG; KOG1205; Eukaryota.
DR   HOGENOM; CLU_010194_2_1_1; -.
DR   InParanoid; A9UM79; -.
DR   OMA; ECYGYVD; -.
DR   OrthoDB; 1313182at2759; -.
DR   TreeFam; TF313474; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012255; Expressed in skeletal muscle tissue and 7 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..311
FT                   /note="Dehydrogenase/reductase SDR family member 7C"
FT                   /id="PRO_0000333759"
FT   ACT_SITE        191
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         41..65
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   311 AA;  34615 MW;  1B170C011817E01B CRC64;
     MGFLTFLIVP LLILGISGIV YIYREVVRLM SRSALKNKVV VITDAISGLG KECSRVFHSA
     GARLVLCGKT WEKLEALHDA LISVADPSVT FTPKLVLLDI SDINNMEAMG KEIQDCYGCV
     DVLINNASMK MKGPLQSVSL ELDKKIMDAN YFGPITLVKA ILPHMISRRT GQIVLVNTIQ
     GKIGVPFRAA YAASKHAIQG FFDCLRAEVE EFDVSVSTVS PTFIRSYHVQ PQPGNWEASI
     WKFFFRKLSY GAHPVEVAEE VLSTVSRKKQ EVFMANPIPR AAVYIRTFLP ELFFAVVATG
     VKEKHFVEEE K