ID   DRS7_PHYTS              Reviewed;          31 AA.
AC   P84927;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Dermaseptin-TA1 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-TA1 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Dermaseptin-7 {ECO:0000303|Ref.1};
DE            Short=DStar 07 {ECO:0000303|Ref.1};
OS   Phyllomedusa tarsius (Brownbelly leaf frog) (Phyllomedusa tarsia).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=306084;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT GLN-31.
RC   TISSUE=Skin secretion;
RA   Prates M.V., Jardim D.P., Silva L.P., Gordo M., Leite J.R.S.A.,
RA   Figueredo R.C.R., Amaral A.C., Felipe M.S.S., Bloch C. Jr.;
RT   "Dermaseptins and phylloseptins from Phyllomedusa tarsius (Amphibia).";
RL   Submitted (AUG-2006) to UniProtKB.
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Antimicrobial peptide, active against the Gram-positive
CC       bacterium S.aureus, and the Gram-negative bacteria E.coli and
CC       P.aeruginosa. Has hemolytic activity at 286 uM. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=3144.83; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0956";
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DR   AlphaFoldDB; P84927; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Hemolysis; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Dermaseptin-TA1"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000376039"
FT   MOD_RES         31
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   31 AA;  3147 MW;  8D411D8540FE59EB CRC64;
     ALWKDVLKKI GTVALHAGKA ALGAVADTIS Q