ID   DRS7_PITHY              Reviewed;          29 AA.
AC   P84600;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Dermaseptin-H7 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-H7 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=DShypo 05 {ECO:0000303|PubMed:16844081};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT LEU-29.
RC   TISSUE=Skin secretion;
RX   PubMed=16844081; DOI=10.1016/j.bbrc.2006.06.168;
RA   Brand G.D., Leite J.R.S.A., de Sa Mandel S.M., Mesquita D.A., Silva L.P.,
RA   Prates M.V., Barbosa E.A., Vinecky F., Martins G.R., Galasso J.H.,
RA   Kuckelhaus S.A.S., Sampaio R.N.R., Furtado J.R. Jr., Andrade A.C.,
RA   Bloch C. Jr.;
RT   "Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).";
RL   Biochem. Biophys. Res. Commun. 347:739-746(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-negative
CC       bacterium E.coli and the Gram-positive bacterium S.aureus
CC       (PubMed:16844081). Has antiprotozoal activity against L.amazonensis
CC       (PubMed:16844081). Has antifungal activity (By similarity). Has no
CC       hemolytic activity (PubMed:16844081). {ECO:0000250|UniProtKB:P83637,
CC       ECO:0000269|PubMed:16844081}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16844081}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16844081}.
CC   -!- MASS SPECTROMETRY: Mass=2793.76; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16844081};
CC   -!- MISCELLANEOUS: The primary structure of this peptide is identical to
CC       that of Dermaseptin 01 from Pithecopus oreades (AC P83637).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=1389";
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DR   AlphaFoldDB; P84600; -.
DR   SMR; P84600; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Fungicide; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Dermaseptin-H7"
FT                   /id="PRO_0000248497"
FT   MOD_RES         29
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:16844081"
SQ   SEQUENCE   29 AA;  2795 MW;  B2B596776E2074C6 CRC64;
     GLWSTIKQKG KEAAIAAAKA AGQAALGAL