ID   DRS9_PHYBI              Reviewed;          77 AA.
AC   P81488; Q90ZK4;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   25-MAR-2003, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Dermaseptin-B9 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-B9 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=Dermaseptin-gene related 3 {ECO:0000303|PubMed:18644413};
DE            Short=Dermaseptin DRG3 {ECO:0000303|PubMed:9540838};
DE   Flags: Precursor;
GN   Name=DRG3;
OS   Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8393;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SYNTHESIS OF 46-75.
RC   TISSUE=Blood;
RX   PubMed=9540838; DOI=10.1016/s0167-4781(97)00194-2;
RA   Fleury Y., Vouille V., Beven L., Amiche M., Wroblewski H., Delfour A.,
RA   Nicolas P.;
RT   "Synthesis, antimicrobial activity and gene structure of a novel member of
RT   the dermaseptin B family.";
RL   Biochim. Biophys. Acta 1396:228-236(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. Exhibits a bactericidal activity
CC       towards several species of mollicutes, firmicutes and gracilicutes.
CC       This peptide is membranotropic and it efficiently depolarizes the
CC       plasma membrane.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0164";
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DR   EMBL; AJ312002; CAC37581.1; -; Genomic_DNA.
DR   AlphaFoldDB; P81488; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   InterPro; IPR016322; FSAP.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
DR   PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cleavage on pair of basic residues; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..43
FT                   /id="PRO_0000007109"
FT   PEPTIDE         46..75
FT                   /note="Dermaseptin-B9"
FT                   /id="PRO_0000007110"
FT   PROPEP          76..77
FT                   /id="PRO_0000007111"
SQ   SEQUENCE   77 AA;  8701 MW;  06562934613C6B38 CRC64;
     MAFLKKSLFL VLFLGLVSLS VCEEEKRENE DEEEQEDDEQ SEEKRALWKT IIKGAGKMIG
     SLAKNLLGSQ AQPESEQ