ID   DRS9_PITHY              Reviewed;          33 AA.
AC   P84880;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Dermaseptin-H9 {ECO:0000303|PubMed:18644413};
DE            Short=DRS-H9 {ECO:0000303|PubMed:18644413};
DE   AltName: Full=DShypo 07 {ECO:0000303|PubMed:16844081};
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND AMIDATION
RP   AT LEU-33.
RC   TISSUE=Skin secretion;
RX   PubMed=16844081; DOI=10.1016/j.bbrc.2006.06.168;
RA   Brand G.D., Leite J.R.S.A., de Sa Mandel S.M., Mesquita D.A., Silva L.P.,
RA   Prates M.V., Barbosa E.A., Vinecky F., Martins G.R., Galasso J.H.,
RA   Kuckelhaus S.A.S., Sampaio R.N.R., Furtado J.R. Jr., Andrade A.C.,
RA   Bloch C. Jr.;
RT   "Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).";
RL   Biochem. Biophys. Res. Commun. 347:739-746(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18644413; DOI=10.1016/j.peptides.2008.06.017;
RA   Amiche M., Ladram A., Nicolas P.;
RT   "A consistent nomenclature of antimicrobial peptides isolated from frogs of
RT   the subfamily Phyllomedusinae.";
RL   Peptides 29:2074-2082(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250|UniProtKB:P83637}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16844081}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16844081}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=0950";
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DR   AlphaFoldDB; P84880; -.
DR   SMR; P84880; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR022731; Dermaseptin.
DR   Pfam; PF12121; DD_K; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Dermaseptin-H9"
FT                   /id="PRO_0000248499"
FT   MOD_RES         33
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:16844081"
SQ   SEQUENCE   33 AA;  3211 MW;  353B9C74C8459A47 CRC64;
     GLWSTIKQKG KEAAIAAAKA AGQAALNAAS EAL