DRT1_PHAJA
ID DRT1_PHAJA Reviewed; 32 AA.
AC P86621;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 25-MAY-2022, entry version 8.
DE RecName: Full=Dermatoxin-J1 {ECO:0000303|PubMed:20932854};
DE Short=DRT-J1 {ECO:0000303|PubMed:20932854};
OS Phasmahyla jandaia (Jandaia leaf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Phasmahyla.
OX NCBI_TaxID=762504;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP SPECTROMETRY, AND AMIDATION AT GLN-32.
RC TISSUE=Skin secretion;
RX PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
RA Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H., Bloch C. Jr.,
RA De Lima M.E., Pimenta A.M.;
RT "Peptidomic dissection of the skin secretion of Phasmahyla jandaia
RT (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
RL Toxicon 57:35-52(2011).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:P84928}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:20932854}.
CC -!- MASS SPECTROMETRY: Mass=3098.0; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20932854};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Dermatoxin subfamily. {ECO:0000255}.
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DR AlphaFoldDB; P86621; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT PEPTIDE 1..32
FT /note="Dermatoxin-J1"
FT /evidence="ECO:0000269|PubMed:20932854"
FT /id="PRO_0000404607"
FT MOD_RES 32
FT /note="Glutamine amide"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 2
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 6
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 7
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 11
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 13
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 18
FT /note="K or Q"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 23
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 27
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 28
FT /note="L or I"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 29
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20932854"
FT UNSURE 32
FT /note="Q or K"
FT /evidence="ECO:0000269|PubMed:20932854"
SQ SEQUENCE 32 AA; 3101 MW; A0B4EC9756C790BE CRC64;
SLGGFLKGVG KALAGVGKVV ADQFGNLLQA GQ