ADF1_CANAL
ID ADF1_CANAL Reviewed; 612 AA.
AC P46589; A0A1D8PKL9; Q5A2X5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Adherence factor;
DE AltName: Full=Adhesion and aggregation mediating surface antigen;
GN Name=ADF1; Synonyms=AAF1; OrderedLocusNames=CAALFM_C306470WA;
GN ORFNames=CaO19.7436;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Jiang W., Finkler A., Koltin Y.;
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-612.
RC STRAIN=ATCC 36082;
RA Edwards J.E.;
RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Surface antigen mediating adhesion and aggregation in
CC S.cerevisiae.
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DR EMBL; U44747; AAA86758.1; -; Genomic_DNA.
DR EMBL; CP017625; AOW28653.1; -; Genomic_DNA.
DR EMBL; U18983; AAA62506.1; -; Genomic_DNA.
DR RefSeq; XP_716097.1; XM_711004.1.
DR AlphaFoldDB; P46589; -.
DR SMR; P46589; -.
DR STRING; 237561.P46589; -.
DR PRIDE; P46589; -.
DR GeneID; 3642284; -.
DR KEGG; cal:CAALFM_C306470WA; -.
DR CGD; CAL0000196141; AAF1.
DR VEuPathDB; FungiDB:C3_06470W_A; -.
DR eggNOG; ENOG502S8GZ; Eukaryota.
DR HOGENOM; CLU_527843_0_0_1; -.
DR InParanoid; P46589; -.
DR OMA; MGISATH; -.
DR OrthoDB; 1240218at2759; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0044406; P:adhesion of symbiont to host; IGI:CGD.
DR GO; GO:0007155; P:cell adhesion; IGI:CGD.
DR GO; GO:0098609; P:cell-cell adhesion; IDA:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IGI:CGD.
PE 4: Predicted;
KW Cell adhesion; Reference proteome.
FT CHAIN 1..612
FT /note="Adherence factor"
FT /id="PRO_0000064451"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 142
FT /note="F -> N (in Ref. 5; AAA62506)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="T -> I (in Ref. 5; AAA62506)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 612 AA; 68794 MW; 77B60E45C35C1B23 CRC64;
MSSFNSNSNP ANAQNLSSFQ FQPPKEDVIF DTHQMSLSVP QSRYYASSMM QQSQQGQPQS
QTSQQQQQQP FLMNIPPAFT QTQPQQMLYA MPPLQTQQPS SSSATTNNVV PPHHYNQQQS
QQQQQQQQQY QQMQPQPNNM QFFDNTIPNY LIMNQTISPS QTQTTAQPNI SYYNYSTQPQ
LQSAQPISHS QPQPQPQATQ PRSNRSRSQT SFSKPRGSRQ VSGSGRSTGA KKQSAITSGS
TGTGPARNAD TGMTSVANST STTTMTTTNN NNKLSVSAPV NVIYANLPER LQQVLPAPPL
SRAPVRPDVT VNLTSKRAKR KSKFTPEQDD MIVNLKKKGK SWVEIAEITG VGSYLAARNR
FQVIVGQQGN NNSSAWDNTD KLFLNQLLDA GEIEKWRFIC CELNKSTNKN FTDYECREMI
RQLFWLNPAS FGVNEETIIE SQKEKKLTEK TIEQREQQRK KRASANHSPP DSDSITNTNN
NQQEVKYIDP QYKNYQSQLM PNQNTGSGAT KISSTTPPPP SQALSNNVNT MNKNIVSSAL
GGTSFSQEQH SLHSNQHHHN HQQHPLIHHH QYQQQSSLPP PPTIPSTIPT SSLSIQQQQQ
QQQQQLYNKQ FY
