ADF1_DROME
ID ADF1_DROME Reviewed; 262 AA.
AC P05552; Q0E9N5; Q9V9C4;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Transcription factor Adf-1;
DE AltName: Full=ADH distal factor 1;
GN Name=Adf1; ORFNames=CG15845;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=1731341; DOI=10.1073/pnas.89.2.683;
RA England B.P., Admon A., Tjian R.;
RT "Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb
RT oncoproteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:683-687(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION.
RX PubMed=2318884; DOI=10.1016/s0021-9258(19)34088-8;
RA England B.P., Heberlein U., Tjian R.;
RT "Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1),
RT binds to sites in several Drosophila promoters and activates
RT transcription.";
RL J. Biol. Chem. 265:5086-5094(1990).
CC -!- FUNCTION: May play an important role not only in the regulation of Adh
CC expression but also in the transcription of other genes.
CC {ECO:0000269|PubMed:1731341, ECO:0000269|PubMed:2318884}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00371,
CC ECO:0000255|PROSITE-ProRule:PRU00372, ECO:0000269|PubMed:1731341}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C;
CC IsoId=P05552-1; Sequence=Displayed;
CC Name=A; Synonyms=B;
CC IsoId=P05552-2; Sequence=VSP_021568;
CC -!- DEVELOPMENTAL STAGE: Expressed during later stages of embryogenesis.
CC {ECO:0000269|PubMed:1731341}.
CC -!- PTM: O-glycosylated; contains N-acetylglucosamine side chains.
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DR EMBL; M37787; AAA28325.1; -; mRNA.
DR EMBL; AE013599; AAF57369.1; -; Genomic_DNA.
DR EMBL; AE013599; AAS64778.1; -; Genomic_DNA.
DR EMBL; AY069387; AAL39532.1; -; mRNA.
DR PIR; A38201; A38201.
DR RefSeq; NP_724481.1; NM_165479.2. [P05552-2]
DR RefSeq; NP_724482.1; NM_165480.2. [P05552-2]
DR RefSeq; NP_995750.1; NM_206028.2. [P05552-1]
DR AlphaFoldDB; P05552; -.
DR SMR; P05552; -.
DR BioGRID; 70573; 17.
DR DIP; DIP-21836N; -.
DR IntAct; P05552; 7.
DR STRING; 7227.FBpp0303283; -.
DR PaxDb; P05552; -.
DR DNASU; 47082; -.
DR EnsemblMetazoa; FBtr0086111; FBpp0085446; FBgn0284249. [P05552-2]
DR EnsemblMetazoa; FBtr0086112; FBpp0085447; FBgn0284249. [P05552-2]
DR EnsemblMetazoa; FBtr0086113; FBpp0089262; FBgn0284249. [P05552-1]
DR GeneID; 47082; -.
DR KEGG; dme:Dmel_CG15845; -.
DR CTD; 47082; -.
DR FlyBase; FBgn0284249; Adf1.
DR VEuPathDB; VectorBase:FBgn0284249; -.
DR eggNOG; ENOG502SCCI; Eukaryota.
DR GeneTree; ENSGT00940000176258; -.
DR HOGENOM; CLU_080630_2_0_1; -.
DR InParanoid; P05552; -.
DR PhylomeDB; P05552; -.
DR SignaLink; P05552; -.
DR ChiTaRS; Adf1; fly.
DR GenomeRNAi; 47082; -.
DR PRO; PR:P05552; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0284249; Expressed in wing disc and 50 other tissues.
DR ExpressionAtlas; P05552; baseline and differential.
DR Genevisible; P05552; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004210; BESS_motif.
DR InterPro; IPR006578; MADF-dom.
DR InterPro; IPR039353; TF_Adf1.
DR PANTHER; PTHR12243; PTHR12243; 1.
DR Pfam; PF10545; MADF_DNA_bdg; 1.
DR SMART; SM00595; MADF; 1.
DR PROSITE; PS51031; BESS; 1.
DR PROSITE; PS51029; MADF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..262
FT /note="Transcription factor Adf-1"
FT /id="PRO_0000064452"
FT DOMAIN 217..256
FT /note="BESS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00371"
FT DNA_BIND 24..104
FT /note="MADF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00372"
FT VAR_SEQ 1..9
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12537569,
FT ECO:0000303|PubMed:1731341"
FT /id="VSP_021568"
SQ SEQUENCE 262 AA; 30188 MW; 0941D5692E7213F8 CRC64;
MHTLTAAIEM DKLDANLEQQ FDLNLIEAVK LNPVIYDRSH YNYKHFVRKA QTWKQIAETL
GVPEQKCTKR WKSLRDKFAR EMKLCQESRW RYFKQMQFLV DSIRQYRESL LGKCANGSQS
ANQVADPSQQ QQAQQQTVVD IFAQPFNGSA TTSAQALTHP HEITVTSDAQ LATAVGKDQK
PYFYEPPLKR ERSEEEHSDN MLNTIKIFQN NVSQAVSAED QSFGMVVTDM LNTLGVRQKA
EAKVHIIKYL TDMQLLAQHN KY
