ID   DRUA_ECOU4              Reviewed;         404 AA.
AC   P0DW34;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Druantia protein DruA {ECO:0000303|PubMed:29371424};
GN   Name=druA {ECO:0000303|PubMed:29371424};
GN   ORFNames=H003_04354 {ECO:0000312|EMBL:ERA40829.1};
OS   Escherichia coli (strain UMEA 4076-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1281278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMEA 4076-1;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Frimodt-Moller N., Leihof R.F., Rasmussen L., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli UMEA 4076-1.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RC   STRAIN=UMEA 4076-1;
RX   PubMed=29371424; DOI=10.1126/science.aar4120;
RA   Doron S., Melamed S., Ofir G., Leavitt A., Lopatina A., Keren M.,
RA   Amitai G., Sorek R.;
RT   "Systematic discovery of antiphage defense systems in the microbial
RT   pangenome.";
RL   Science 359:0-0(2018).
CC   -!- FUNCTION: Component of antiviral defense system Druantia type I,
CC       composed of DruA, DruB, DruC, DruD and DruE. Expression of Druantia in
CC       E.coli (strain MG1655) confers resistance to phage lambda, SECphi18,
CC       SECphi27 and T4. {ECO:0000269|PubMed:29371424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AWEM01000032; ERA40829.1; -; Genomic_DNA.
PE   4: Predicted;
KW   Antiviral defense; Cytoplasm.
FT   CHAIN           1..404
FT                   /note="Druantia protein DruA"
FT                   /id="PRO_0000456314"
SQ   SEQUENCE   404 AA;  45438 MW;  E0219A727A580009 CRC64;
     MHKDPSIIVN INLREAKLKK KVREHLQSLG FTRSDSGALQ APGNTKDVIR ALHSSQRAER
     IFANQKFITL RAAKLIKFFA SGNEVIPDKI SPVLERVKSG TWQGDLFRLA ALTWSVPVSS
     GFGRRLRYLV WDESNGKLIG LIAIGDPVFN LAVRDNLIGW DTHARSSRLV NLMDAYVLGA
     LPPYNALLGG KLIACLLRSR DLYDDFAKVY GDTVGVISQK KKQARLLAIT TTSSMGRSSV
     YNRLKLDGIQ YLKSIGYTGG WGHFHIPDSL FIELRDYLRD MDHAYADHYM FGNGPNWRLR
     TTKAALNVLG FRDNLMKHGI QREVFISQLA ENATSILQTG KGEPDLTSLL SAKEIAECAM
     ARWMVPRSIR NPEYRLWKAR DLFDFISNDS LKFPPSDEIA KTVV