ID   DRUC_ECOU4              Reviewed;         627 AA.
AC   P0DW36;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Druantia protein DruC {ECO:0000303|PubMed:29371424};
GN   Name=druC {ECO:0000303|PubMed:29371424};
GN   ORFNames=H003_04356 {ECO:0000312|EMBL:ERA40831.1};
OS   Escherichia coli (strain UMEA 4076-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1281278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMEA 4076-1;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Frimodt-Moller N., Leihof R.F., Rasmussen L., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli UMEA 4076-1.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=UMEA 4076-1;
RX   PubMed=29371424; DOI=10.1126/science.aar4120;
RA   Doron S., Melamed S., Ofir G., Leavitt A., Lopatina A., Keren M.,
RA   Amitai G., Sorek R.;
RT   "Systematic discovery of antiphage defense systems in the microbial
RT   pangenome.";
RL   Science 359:0-0(2018).
CC   -!- FUNCTION: Component of antiviral defense system Druantia type I,
CC       composed of DruA, DruB, DruC, DruD and DruE. Expression of Druantia in
CC       E.coli (strain MG1655) confers resistance to phage lambda, SECphi18,
CC       SECphi27 and T4. {ECO:0000269|PubMed:29371424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: When this gene is missing the Druantia system
CC       does not confer resistance to SECphi27 in E.coli.
CC       {ECO:0000269|PubMed:29371424}.
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DR   EMBL; AWEM01000032; ERA40831.1; -; Genomic_DNA.
PE   4: Predicted;
KW   Antiviral defense; Cytoplasm.
FT   CHAIN           1..627
FT                   /note="Druantia protein DruC"
FT                   /id="PRO_0000456316"
SQ   SEQUENCE   627 AA;  71180 MW;  F521E92E061D9CD3 CRC64;
     MSYQYSQEAK ERISKLGQSE IVNFINEISP TLRRKAFGCL PKVPGFRAGH PTEIKEKQKR
     LIGYMFQSHP SSEERKAWKS FSLFWQFWAE EKIDKSFSMI DNLGLKENSG SIFIRELAKN
     FPKVARENIE RLFIFSGFAD DPDVINAFNL FPPAVVLARD IVVDTLPIRL DELEARISLI
     ADNVEKKNNH IKELELKIDA FSERFDNYFN NEKSNLKIIN ELQSLINSET KQSDIANKSI
     DELYHFNEKN KQLILSLQEK LDFNALAMND ISEHEKLIKS MANEISELKN ALTILCDNKR
     KNNELDYINE LKKLTERIDT LEINTSQASK VSVTNRFTKF HEIAHYENYE YLSSSEDISN
     RISLNLQAVG LTKNSAETLA RLTLATFVSG QIIQFSGSLA DIIADAIAIA IGAPRYHIWR
     VPVGIISDMD SFDFIETIAE SSRCLLLKGA NLSAFEIYGA AIRDIVVQRQ IHPTNYDHLA
     LIATWKQGPA TFPDGGMLAE LGPVIDTDTL KMRGLSAILP QLKPGCLAKD KWTNIDGLQL
     DSVDDYVDEL RALLDEAGFD GGTLWKRMVH IFYTSLIRVP NGNYIYDLYS VLSFYTLTWA
     KIKGGPVQKI EDIANRELKN YSAKISS