ID   DRUD_ECOU4              Reviewed;         347 AA.
AC   P0DW37;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Druantia protein DruD {ECO:0000303|PubMed:29371424};
GN   Name=druD {ECO:0000303|PubMed:29371424};
GN   ORFNames=H003_04357 {ECO:0000312|EMBL:ERA40832.1};
OS   Escherichia coli (strain UMEA 4076-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1281278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMEA 4076-1;
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Frimodt-Moller N., Leihof R.F., Rasmussen L., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli UMEA 4076-1.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=UMEA 4076-1;
RX   PubMed=29371424; DOI=10.1126/science.aar4120;
RA   Doron S., Melamed S., Ofir G., Leavitt A., Lopatina A., Keren M.,
RA   Amitai G., Sorek R.;
RT   "Systematic discovery of antiphage defense systems in the microbial
RT   pangenome.";
RL   Science 359:0-0(2018).
CC   -!- FUNCTION: Component of antiviral defense system Druantia type I,
CC       composed of DruA, DruB, DruC, DruD and DruE. Expression of Druantia in
CC       E.coli (strain MG1655) confers resistance to phage lambda, SECphi18,
CC       SECphi27 and T4. {ECO:0000269|PubMed:29371424}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: When this gene is missing the Druantia system
CC       does not confer resistance to SECphi27 in E.coli.
CC       {ECO:0000269|PubMed:29371424}.
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DR   EMBL; AWEM01000032; ERA40832.1; -; Genomic_DNA.
PE   4: Predicted;
KW   Antiviral defense; Cytoplasm.
FT   CHAIN           1..347
FT                   /note="Druantia protein DruD"
FT                   /id="PRO_0000456317"
SQ   SEQUENCE   347 AA;  39296 MW;  958126297F91DF7E CRC64;
     MEWRAVSRDK ALDMLSTALN CRFDDEGLRI SAVSECLRSV LYQYSISETE EARQTVTSLR
     LTSAVRRKLV PLWPDIADID NAIHPGIMSI LNSLAELGDM IKLEGGNWLT APPHAVRIDN
     KMAVFFGGEP SCTFSTGVVA KSAGRVRLVE EKVCTGSVEI WDANEWIGAP AEGNEEWSSR
     LLSGTISGFI DAPSNMSETT AYVRGKWLHL SELSFNKKQI YLCRMSVDNH FSYYLGEIEA
     GRLCRMNSLE SSDDVRRLRF FLDTKDNCPL KIRIKISNGL ARLRLTRRLP RRETKVLLLG
     WRESGFENEH SGITHHVFPE EILPIVRSAF EGLGIIWINE FTRRNEI