ID   DRXIA_SALSA             Reviewed;         382 AA.
AC   B5X216;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Draxin-A {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal inhibitory axon guidance protein A {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal repulsive axon guidance protein A {ECO:0000255|HAMAP-Rule:MF_03060};
DE   Flags: Precursor;
GN   Name=draxin-A;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord. {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SIMILARITY: Belongs to the draxin family. {ECO:0000255|HAMAP-
CC       Rule:MF_03060}.
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DR   EMBL; BT045085; ACI33347.1; -; mRNA.
DR   RefSeq; XP_013989060.1; XM_014133585.1.
DR   RefSeq; XP_013989061.1; XM_014133586.1.
DR   RefSeq; XP_013989062.1; XM_014133587.1.
DR   RefSeq; XP_013989063.1; XM_014133588.1.
DR   RefSeq; XP_013989064.1; XM_014133589.1.
DR   RefSeq; XP_013989066.1; XM_014133591.1.
DR   AlphaFoldDB; B5X216; -.
DR   SMR; B5X216; -.
DR   GeneID; 106565906; -.
DR   KEGG; sasa:106565906; -.
DR   OMA; GHGHHFE; -.
DR   OrthoDB; 860902at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa12.
DR   Bgee; ENSSSAG00000069005; Expressed in mesonephros and 5 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProtKB-UniRule.
DR   GO; GO:0021528; P:commissural neuron differentiation in spinal cord; IEA:UniProtKB-UniRule.
DR   GO; GO:0021516; P:dorsal spinal cord development; IEA:UniProtKB-UniRule.
DR   GO; GO:0030900; P:forebrain development; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro.
DR   HAMAP; MF_03060; Draxin; 1.
DR   InterPro; IPR029094; Draxin.
DR   PANTHER; PTHR28610; PTHR28610; 1.
DR   Pfam; PF15550; Draxin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CHAIN           23..382
FT                   /note="Draxin-A"
FT                   /id="PRO_0000365950"
FT   REGION          28..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..163
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        291
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CARBOHYD        296
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
SQ   SEQUENCE   382 AA;  41528 MW;  5F7D6E51545B53C5 CRC64;
     MMSSSWCLPL ALLFSTLAVS HSAEPGSTHA KRRLAQPLPG SGNALQYPDQ GFQSHGHGHG
     RERGGGHGGQ GSRGAKASSG AGLLSRRPLH PAARPEDDGT GLEGLNPVRL EMGPVGREQE
     KGHGGFRNPS HARDNHPLGP RKGRGQGHGH HFDQRRHGGR RDKGRLTKGF LPEPELGSVL
     KNRDLSEEGS VSSAAAATSP SHRLTPPTEP PSPIYAVFGS GSYAVSTVMS EHLPTLPPAS
     TKPQKSGRGK MQGEVMPTLD MTLFDWTDYE DMKPVDAWPS SRKKDKRRSK NLSSGNVTVD
     TDAIEPCDHH LDCLPGSCCD LRQHECKPHN RGLNNKCYDD CMCEEGFRCY AKFHRKRRVT
     RRRGRCVVPE SANSDQGAFI TV