ID   DRXIB_SALSA             Reviewed;         353 AA.
AC   B5X1Q3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Draxin-B {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal inhibitory axon guidance protein B {ECO:0000255|HAMAP-Rule:MF_03060};
DE   AltName: Full=Dorsal repulsive axon guidance protein B {ECO:0000255|HAMAP-Rule:MF_03060};
DE   Flags: Precursor;
GN   Name=draxin-B;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Chemorepulsive axon guidance protein required for the
CC       development of spinal cord and forebrain commissures. Acts as a
CC       chemorepulsive guidance protein for commissural axons during
CC       development. Able to inhibit or repel neurite outgrowth from dorsal
CC       spinal cord. {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_03060}.
CC   -!- SIMILARITY: Belongs to the draxin family. {ECO:0000255|HAMAP-
CC       Rule:MF_03060}.
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DR   EMBL; BT044972; ACI33234.1; -; mRNA.
DR   RefSeq; XP_014022093.1; XM_014166618.1.
DR   RefSeq; XP_014022094.1; XM_014166619.1.
DR   RefSeq; XP_014022095.1; XM_014166620.1.
DR   RefSeq; XP_014022096.1; XM_014166621.1.
DR   AlphaFoldDB; B5X1Q3; -.
DR   SMR; B5X1Q3; -.
DR   PRIDE; B5X1Q3; -.
DR   GeneID; 106582973; -.
DR   KEGG; sasa:106582973; -.
DR   OMA; SHARENH; -.
DR   OrthoDB; 860902at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa22.
DR   Bgee; ENSSSAG00000070721; Expressed in brain and 11 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProtKB-UniRule.
DR   GO; GO:0021528; P:commissural neuron differentiation in spinal cord; IEA:UniProtKB-UniRule.
DR   GO; GO:0021516; P:dorsal spinal cord development; IEA:UniProtKB-UniRule.
DR   GO; GO:0030900; P:forebrain development; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro.
DR   HAMAP; MF_03060; Draxin; 1.
DR   InterPro; IPR029094; Draxin.
DR   PANTHER; PTHR28610; PTHR28610; 1.
DR   Pfam; PF15550; Draxin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CHAIN           22..353
FT                   /note="Draxin-B"
FT                   /id="PRO_0000365951"
FT   REGION          23..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..163
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        262
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
FT   CARBOHYD        267
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03060"
SQ   SEQUENCE   353 AA;  38575 MW;  54A5E374C73FC198 CRC64;
     MASSWCLPLA LLVSNLAVSH SAEPSSTHAK RRLAQPSPGN GNALQYPEQG FQSHGHGNVR
     ERGGRHGGQG AHSAKANTGA GLLSRSPLHP AARHEDDGTG LDGLSPVRLE MGPGGREREN
     GRGGFRNPSH ARENHPLGPH KGKAQGHGHH FDHRRHGGRR DKGRHTKGFF PEPELDSSLK
     EGSVSSTIFG SGSSAVTTVM SEHPPMLPPA STKPKKSGRG KVQGEVMPTL DMTLFDWTDY
     EDMKPVDAWP SSRKKDKRRS KNLSSGNVTV DSDAIEPCDH HLDCLPGSCC DLRQHECKLH
     NRGLNNKCYD DCMCEEGFRC YAKFHRKLHV TRRRGRCVVP ESANRDQGAF ITV