ID   DS7CB_DANRE             Reviewed;         318 AA.
AC   Q5BL28;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 7C-B;
DE            EC=1.1.-.-;
DE   Flags: Precursor;
GN   Name=dhrs7cb; ORFNames=zgc:101633;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC090822; AAH90822.1; -; mRNA.
DR   RefSeq; NP_001013557.1; NM_001013539.1.
DR   AlphaFoldDB; Q5BL28; -.
DR   SMR; Q5BL28; -.
DR   STRING; 7955.ENSDARP00000057639; -.
DR   PaxDb; Q5BL28; -.
DR   GeneID; 558764; -.
DR   KEGG; dre:558764; -.
DR   CTD; 558764; -.
DR   ZFIN; ZDB-GENE-050320-114; dhrs7ca.
DR   eggNOG; KOG1205; Eukaryota.
DR   InParanoid; Q5BL28; -.
DR   OrthoDB; 1313182at2759; -.
DR   PhylomeDB; Q5BL28; -.
DR   PRO; PR:Q5BL28; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..318
FT                   /note="Dehydrogenase/reductase SDR family member 7C-B"
FT                   /id="PRO_0000333758"
FT   ACT_SITE        199
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         49..73
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         186
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  35307 MW;  064CC3AB542EA3BB CRC64;
     MGMSDIMWLD VSWAWLVLTA VLLAAAVFYL YTLILSHLAK TTVRNKVVLI TDSLSTVGNE
     CAKLFHAGGA RLILCGSNWE KLEALAEQLT SQSDPTLTFP PKLVELDFSD MESVPEVISE
     ILECFCCLDV LVFNSSMKLK APVHSLSLQM DRLLMDVNYF GPITLVKGFL PSLISRRSGH
     ILLVNSIQGK LAMPFRTTYA ASKHAVQAFF ECLRAEVQEY GITVSTINHT FIKTSSSIPK
     DEITARSMKT DHRQTPLGVS PKDVATELLR TLSSKKKEIL MARWVPKAAL YVRSLFPNLF
     FAIMAARVSN TVAETPDD