ID   DSBA_AZOVI              Reviewed;         214 AA.
AC   Q44504;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Thiol:disulfide interchange protein DsbA;
DE   Flags: Precursor;
GN   Name=dsbA;
OS   Azotobacter vinelandii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Azotobacter.
OX   NCBI_TaxID=354;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CA;
RX   PubMed=9099867; DOI=10.1016/s0378-1119(96)00792-5;
RA   Ng T.C.N., Kwik J.F., Maier R.J.;
RT   "Cloning and expression of the gene for a protein disulfide oxidoreductase
RT   from Azotobacter vinelandii: complementation of an Escherichia coli dsbA
RT   mutant strain.";
RL   Gene 188:109-113(1997).
CC   -!- FUNCTION: Involved in disulfide-bond formation. Acts by transferring
CC       its disulfide bond to other proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. DsbA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L76098; AAB53016.1; -; Genomic_DNA.
DR   RefSeq; WP_012698888.1; NZ_FPKM01000002.1.
DR   AlphaFoldDB; Q44504; -.
DR   SMR; Q44504; -.
DR   OMA; EVVEFFW; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProt.
DR   CDD; cd03019; DsbA_DsbA; 1.
DR   InterPro; IPR001853; DSBA-like_thioredoxin_dom.
DR   InterPro; IPR023205; DsbA/DsbL.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF01323; DSBA; 1.
DR   PIRSF; PIRSF001488; Tdi_protein; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Periplasm; Redox-active center; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..214
FT                   /note="Thiol:disulfide interchange protein DsbA"
FT                   /id="PRO_0000034247"
FT   DOMAIN          18..208
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        61..64
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   214 AA;  23446 MW;  47DC6A43478B0EE7 CRC64;
     MRKLILGAIL AGTSLFALGT QAESLSPADI KIGRQYVELP THVPVAQPGK IEVVELFWYG
     CPHCYQFEPS INAWAGKLPE DVSFRRVPAL FGGLWNIHGQ LFLTLEAMGV EPKVHTAIFD
     AIHKDGKKLA TPEEMAEFLA GHGIDKDAFL KAYGSFNVKS QMEKAKKLAI AYQISGVPVM
     VVNGKYRFDL GSAGGPENTL QVADYLIEQE RSAQ