ID   DSBA_BORPE              Reviewed;         209 AA.
AC   Q7W0K2;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Thiol:disulfide interchange protein DsbA;
DE   Flags: Precursor;
GN   Name=dsbA; OrderedLocusNames=BP0113;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   FUNCTION IN PERTUSSIS TOXIN SECRETION.
RC   STRAIN=Tohama I / BP338;
RX   PubMed=11953363; DOI=10.1128/iai.70.5.2297-2303.2002;
RA   Stenson T.H., Weiss A.A.;
RT   "DsbA and DsbC are required for secretion of pertussis toxin by Bordetella
RT   pertussis.";
RL   Infect. Immun. 70:2297-2303(2002).
CC   -!- FUNCTION: Involved in disulfide-bond formation. Acts by transferring
CC       its disulfide bond to other proteins (By similarity). Required for
CC       periplasmic assembly of the pertussis toxin (PTX). {ECO:0000250,
CC       ECO:0000269|PubMed:11953363}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. DsbA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BX640411; CAE40493.1; -; Genomic_DNA.
DR   RefSeq; NP_879015.1; NC_002929.2.
DR   RefSeq; WP_010929628.1; NZ_CP039022.1.
DR   AlphaFoldDB; Q7W0K2; -.
DR   SMR; Q7W0K2; -.
DR   STRING; 257313.BP0113; -.
DR   GeneID; 45390603; -.
DR   KEGG; bpe:BP0113; -.
DR   PATRIC; fig|257313.5.peg.115; -.
DR   eggNOG; COG1651; Bacteria.
DR   HOGENOM; CLU_088255_1_0_4; -.
DR   OMA; EVVEFFW; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProt.
DR   CDD; cd03019; DsbA_DsbA; 1.
DR   InterPro; IPR001853; DSBA-like_thioredoxin_dom.
DR   InterPro; IPR023205; DsbA/DsbL.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF01323; DSBA; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PIRSF; PIRSF001488; Tdi_protein; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Periplasm; Redox-active center; Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..209
FT                   /note="Thiol:disulfide interchange protein DsbA"
FT                   /id="PRO_0000245632"
FT   DISULFID        58..61
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   209 AA;  22784 MW;  9891E9CD35C39E22 CRC64;
     MQSTTFTRLL AAAALGATTL FAPATQAQGA QQYVNINPPM PSDTPGKIEV LEFFAYTCPH
     CAAIEPMVED WAKTAPQDVV LKQVPIAFNA GMKPLQQLYY TLQALERPDL HPKVFTAIHT
     ERKRLFDKKA MGEWAASQGV DRAKFDSVFD SFSVQTQVQH ASQLAEAAHI DGTPAFAVGG
     RYMTSPVLAG NDYAGALKVV DQLIVQSRK