ID   DSBA_LEGPN              Reviewed;         204 AA.
AC   P50024;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Thiol:disulfide interchange protein DsbA;
DE   Flags: Precursor;
GN   Name=dsbA;
OS   Legionella pneumophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JR32;
RA   Sadosky A.B., Shuman H.A.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in disulfide-bond formation. Acts by transferring
CC       its disulfide bond to other proteins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. DsbA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U15278; AAA67725.1; -; Genomic_DNA.
DR   AlphaFoldDB; P50024; -.
DR   SMR; P50024; -.
DR   STRING; 91892.BIZ52_00645; -.
DR   eggNOG; COG1651; Bacteria.
DR   BRENDA; 1.8.4.2; 2943.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProt.
DR   CDD; cd03019; DsbA_DsbA; 1.
DR   InterPro; IPR001853; DSBA-like_thioredoxin_dom.
DR   InterPro; IPR023205; DsbA/DsbL.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF01323; DSBA; 1.
DR   PIRSF; PIRSF001488; Tdi_protein; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Periplasm; Redox-active center; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..204
FT                   /note="Thiol:disulfide interchange protein DsbA"
FT                   /id="PRO_0000034261"
FT   DOMAIN          19..146
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        53..56
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   204 AA;  23146 MW;  8234634690B147AE CRC64;
     MFKKLIGLLF LMPMTALATQ FIEGKDYQTV ASAQLSTNKD KTPLITEFFS YGCPWCYKID
     APLNDWATRM GKGAHLERVP VVFKPNWDLY AKAYYTAKTL AMSDKMNPIL FKAIQEDKNP
     LATKQSMVDF FVAHGVDREI AKSAFENSPT IDMRVNSGMS LMAHYQINAV PAFVVNNKYK
     TDLQMAGSEE RLFEILNYLV RKSA