ADF3_ARATH
ID ADF3_ARATH Reviewed; 139 AA.
AC Q9ZSK4;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Actin-depolymerizing factor 3;
DE Short=ADF-3;
DE Short=AtADF3;
GN Name=ADF3; OrderedLocusNames=At5g59880; ORFNames=MMN10.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11414611; DOI=10.1023/a:1010687911374;
RA Dong C.-H., Kost B., Xia G.-X., Chua N.-H.;
RT "Molecular identification and characterization of the Arabidopsis AtADF1,
RT AtADF5 and AtADF6 genes.";
RL Plant Mol. Biol. 45:517-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16360805; DOI=10.1016/j.jplph.2005.01.015;
RA Feng Y., Liu Q., Xue Q.;
RT "Comparative study of rice and Arabidopsis actin-depolymerizing factors
RT gene families.";
RL J. Plant Physiol. 163:69-79(2006).
RN [7]
RP INDUCTION.
RX PubMed=19794115; DOI=10.1105/tpc.109.069104;
RA Clement M., Ketelaar T., Rodiuc N., Banora M.Y., Smertenko A., Engler G.,
RA Abad P., Hussey P.J., de Almeida Engler J.;
RT "Actin-depolymerizing factor2-mediated actin dynamics are essential for
RT root-knot nematode infection of Arabidopsis.";
RL Plant Cell 21:2963-2979(2009).
CC -!- FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-
CC actin) and binds to actin monomers. {ECO:0000250|UniProtKB:Q39251}.
CC -!- INTERACTION:
CC Q9ZSK4; Q39016: CPK11; NbExp=5; IntAct=EBI-2009725, EBI-979321;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q39250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9ZSK4-1; Sequence=Displayed;
CC -!- INDUCTION: By the root-knot nematode Meloidogyne incognita.
CC {ECO:0000269|PubMed:19794115}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
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DR EMBL; AF102821; AAD09109.1; -; mRNA.
DR EMBL; AB015475; BAB08356.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97245.1; -; Genomic_DNA.
DR EMBL; AF360169; AAK25879.1; -; mRNA.
DR EMBL; AY050334; AAK91351.1; -; mRNA.
DR EMBL; AY056345; AAL07194.1; -; mRNA.
DR EMBL; AY094033; AAM16189.1; -; mRNA.
DR EMBL; AY086069; AAM63276.1; -; mRNA.
DR RefSeq; NP_851227.1; NM_180896.3. [Q9ZSK4-1]
DR AlphaFoldDB; Q9ZSK4; -.
DR SMR; Q9ZSK4; -.
DR BioGRID; 21354; 5.
DR IntAct; Q9ZSK4; 3.
DR STRING; 3702.AT5G59880.1; -.
DR iPTMnet; Q9ZSK4; -.
DR SwissPalm; Q9ZSK4; -.
DR PaxDb; Q9ZSK4; -.
DR PRIDE; Q9ZSK4; -.
DR ProteomicsDB; 244655; -. [Q9ZSK4-1]
DR EnsemblPlants; AT5G59880.1; AT5G59880.1; AT5G59880. [Q9ZSK4-1]
DR GeneID; 836110; -.
DR Gramene; AT5G59880.1; AT5G59880.1; AT5G59880. [Q9ZSK4-1]
DR KEGG; ath:AT5G59880; -.
DR Araport; AT5G59880; -.
DR TAIR; locus:2168052; AT5G59880.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_094004_2_2_1; -.
DR InParanoid; Q9ZSK4; -.
DR OMA; PPEFMAN; -.
DR PhylomeDB; Q9ZSK4; -.
DR PRO; PR:Q9ZSK4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9ZSK4; baseline and differential.
DR Genevisible; Q9ZSK4; AT.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030042; P:actin filament depolymerization; IDA:TAIR.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..139
FT /note="Actin-depolymerizing factor 3"
FT /id="PRO_0000214925"
FT DOMAIN 5..139
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q39250"
SQ SEQUENCE 139 AA; 15922 MW; D3325AA71D0D102E CRC64;
MANAASGMAV HDDCKLKFME LKTKRTHRFI IYKIEELQKQ VIVEKIGEPG QTHEDLAASL
PADECRYAIF DFDFVSSEGV PRSRIFFVAW SPDTARVRSK MIYASSKDRF KRELDGIQVE
LQATDPTEMD LDVFKSRAN
