ADF5_ARATH
ID ADF5_ARATH Reviewed; 143 AA.
AC Q9ZNT3; Q9SLE7;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Actin-depolymerizing factor 5;
DE Short=ADF-5;
DE Short=AtADF5;
GN Name=ADF5; OrderedLocusNames=At2g16700; ORFNames=T24I21.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP CHARACTERIZATION.
RC STRAIN=cv. Columbia;
RX PubMed=11414611; DOI=10.1023/a:1010687911374;
RA Dong C.-H., Kost B., Xia G.-X., Chua N.-H.;
RT "Molecular identification and characterization of the Arabidopsis AtADF1,
RT AtADF5 and AtADF6 genes.";
RL Plant Mol. Biol. 45:517-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16360805; DOI=10.1016/j.jplph.2005.01.015;
RA Feng Y., Liu Q., Xue Q.;
RT "Comparative study of rice and Arabidopsis actin-depolymerizing factors
RT gene families.";
RL J. Plant Physiol. 163:69-79(2006).
RN [7]
RP INDUCTION.
RX PubMed=19794115; DOI=10.1105/tpc.109.069104;
RA Clement M., Ketelaar T., Rodiuc N., Banora M.Y., Smertenko A., Engler G.,
RA Abad P., Hussey P.J., de Almeida Engler J.;
RT "Actin-depolymerizing factor2-mediated actin dynamics are essential for
RT root-knot nematode infection of Arabidopsis.";
RL Plant Cell 21:2963-2979(2009).
CC -!- FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-
CC actin) and binds to actin monomers. {ECO:0000269|PubMed:11414611}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q9ZSK3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9ZNT3-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed exclusively in root tip meristem.
CC {ECO:0000269|PubMed:11414611}.
CC -!- INDUCTION: By the root-knot nematode Meloidogyne incognita.
CC {ECO:0000269|PubMed:19794115}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF102825; AAD09113.1; -; Genomic_DNA.
DR EMBL; AF102823; AAD09111.1; -; mRNA.
DR EMBL; AC005825; AAD24603.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC06526.1; -; Genomic_DNA.
DR EMBL; AF360302; AAK26012.1; -; mRNA.
DR EMBL; AY051065; AAK93742.1; -; mRNA.
DR EMBL; AY086707; AAM63761.1; -; mRNA.
DR PIR; B84543; B84543.
DR RefSeq; NP_565390.1; NM_127222.5. [Q9ZNT3-1]
DR AlphaFoldDB; Q9ZNT3; -.
DR SMR; Q9ZNT3; -.
DR STRING; 3702.AT2G16700.1; -.
DR PaxDb; Q9ZNT3; -.
DR PRIDE; Q9ZNT3; -.
DR ProteomicsDB; 244855; -. [Q9ZNT3-1]
DR EnsemblPlants; AT2G16700.1; AT2G16700.1; AT2G16700. [Q9ZNT3-1]
DR GeneID; 816171; -.
DR Gramene; AT2G16700.1; AT2G16700.1; AT2G16700. [Q9ZNT3-1]
DR KEGG; ath:AT2G16700; -.
DR Araport; AT2G16700; -.
DR TAIR; locus:2059861; AT2G16700.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_094004_2_2_1; -.
DR InParanoid; Q9ZNT3; -.
DR OMA; DPYGCFV; -.
DR PhylomeDB; Q9ZNT3; -.
DR PRO; PR:Q9ZNT3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZNT3; baseline and differential.
DR Genevisible; Q9ZNT3; AT.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0051017; P:actin filament bundle assembly; IDA:TAIR.
DR GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..143
FT /note="Actin-depolymerizing factor 5"
FT /id="PRO_0000214927"
FT DOMAIN 11..143
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ SEQUENCE 143 AA; 16468 MW; 570BF0222BE043CA CRC64;
MAMAFKMATT GMRVTDECTS SFMDMKWKKV HRYIVFKIEE KSRKVTVDKV GGAGESYHDL
EDSLPVDDCR YAVFDFDFVT VDNCRKSKIF FIAWSPEASK IRAKILYATS KDGLRRVLEG
IHYELQATDP TEMGFDIIQD RAK
