ADF6_ARATH
ID ADF6_ARATH Reviewed; 146 AA.
AC Q9ZSK2; Q8LCM6; Q93VZ4; Q9SJX6;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Actin-depolymerizing factor 6;
DE Short=ADF-6;
DE Short=AtADF6;
GN Name=ADF6; OrderedLocusNames=At2g31200; ORFNames=F16D14.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP CHARACTERIZATION.
RC STRAIN=cv. Columbia;
RX PubMed=11414611; DOI=10.1023/a:1010687911374;
RA Dong C.-H., Kost B., Xia G.-X., Chua N.-H.;
RT "Molecular identification and characterization of the Arabidopsis AtADF1,
RT AtADF5 and AtADF6 genes.";
RL Plant Mol. Biol. 45:517-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16360805; DOI=10.1016/j.jplph.2005.01.015;
RA Feng Y., Liu Q., Xue Q.;
RT "Comparative study of rice and Arabidopsis actin-depolymerizing factors
RT gene families.";
RL J. Plant Physiol. 163:69-79(2006).
RN [7]
RP INDUCTION.
RX PubMed=19794115; DOI=10.1105/tpc.109.069104;
RA Clement M., Ketelaar T., Rodiuc N., Banora M.Y., Smertenko A., Engler G.,
RA Abad P., Hussey P.J., de Almeida Engler J.;
RT "Actin-depolymerizing factor2-mediated actin dynamics are essential for
RT root-knot nematode infection of Arabidopsis.";
RL Plant Cell 21:2963-2979(2009).
CC -!- FUNCTION: Actin-depolymerizing protein. Severs actin filaments (F-
CC actin) and binds to actin monomers. {ECO:0000269|PubMed:11414611}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q9ZSK3}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular tissues of all organs.
CC {ECO:0000269|PubMed:11414611}.
CC -!- INDUCTION: By the root-knot nematode Meloidogyne incognita.
CC {ECO:0000269|PubMed:19794115}.
CC -!- PTM: Phosphorylated.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK49596.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF102824; AAD09112.1; -; mRNA.
DR EMBL; AF183576; AAF01035.1; -; Genomic_DNA.
DR EMBL; AC006593; AAD20665.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC08507.1; -; Genomic_DNA.
DR EMBL; AY057719; AAL15349.1; -; mRNA.
DR EMBL; AF372880; AAK49596.1; ALT_INIT; mRNA.
DR EMBL; AY086510; AAM63510.1; -; mRNA.
DR PIR; G84717; G84717.
DR RefSeq; NP_565719.1; NM_128676.5.
DR AlphaFoldDB; Q9ZSK2; -.
DR SMR; Q9ZSK2; -.
DR BioGRID; 3024; 4.
DR IntAct; Q9ZSK2; 4.
DR STRING; 3702.AT2G31200.1; -.
DR PaxDb; Q9ZSK2; -.
DR PRIDE; Q9ZSK2; -.
DR ProteomicsDB; 244856; -.
DR EnsemblPlants; AT2G31200.1; AT2G31200.1; AT2G31200.
DR GeneID; 817676; -.
DR Gramene; AT2G31200.1; AT2G31200.1; AT2G31200.
DR KEGG; ath:AT2G31200; -.
DR Araport; AT2G31200; -.
DR TAIR; locus:2042546; AT2G31200.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_094004_2_2_1; -.
DR InParanoid; Q9ZSK2; -.
DR OMA; ITFYSWS; -.
DR OrthoDB; 1370477at2759; -.
DR PhylomeDB; Q9ZSK2; -.
DR PRO; PR:Q9ZSK2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZSK2; baseline and differential.
DR Genevisible; Q9ZSK2; AT.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030042; P:actin filament depolymerization; IDA:TAIR.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..146
FT /note="Actin-depolymerizing factor 6"
FT /id="PRO_0000214928"
FT DOMAIN 14..146
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q39250"
FT CONFLICT 1
FT /note="M -> L (in Ref. 4; AAK49596)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="A -> S (in Ref. 5; AAM63510)"
FT /evidence="ECO:0000305"
FT CONFLICT 103..104
FT /note="GI -> PV (in Ref. 5; AAM63510)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="R -> K (in Ref. 5; AAM63510)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 16708 MW; A97CEF5D2CC17A85 CRC64;
MSFRGLSRPN AISGMGVADE SKTTFLELQR KKTHRYVVFK IDESKKEVVV EKTGNPTESY
DDFLASLPDN DCRYAVYDFD FVTSENCQKS KIFFFAWSPS TSGIRAKVLY STSKDQLSRE
LQGIHYEIQA TDPTEVDLEV LRERAN
