ID   ADFA_TENMO              Reviewed;          14 AA.
AC   P82965;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Antidiuretic factor A;
DE            Short=ADF;
DE            Short=ADFa;
DE   AltName: Full=Antidiuretic hormone A;
DE            Short=ADHA;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=Head;
RX   PubMed=11756661; DOI=10.1073/pnas.012436199;
RA   Eigenheer R.A., Nicolson S.W., Schegg K.M., Hull J.J., Schooley D.A.;
RT   "Identification of a potent antidiuretic factor acting on beetle Malpighian
RT   tubules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:84-89(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=11893763; DOI=10.1242/jeb.205.4.493;
RA   Wiehart U.I.M., Nicolson S.W., Eigenheer R.A., Schooley D.A.;
RT   "Antagonistic control of fluid secretion by the Malpighian tubules of
RT   Tenebrio molitor: effects of diuretic and antidiuretic peptides and their
RT   second messengers.";
RL   J. Exp. Biol. 205:493-501(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=15235016; DOI=10.1242/jeb.01102;
RA   Massaro R.C., Lee L.W., Patel A.B., Wu D.S., Yu M.-J., Scott B.N.,
RA   Schooley D.A., Schegg K.M., Beyenbach K.W.;
RT   "The mechanism of action of the antidiuretic peptide Tenmo ADFa in
RT   Malpighian tubules of Aedes aegypti.";
RL   J. Exp. Biol. 207:2877-2888(2004).
CC   -!- FUNCTION: Strong inhibitor of fluid secretion by the Malpighian
CC       tubules. Uses cGMP as a second messenger and inhibits fluid production
CC       by decreasing cAMP concentration. Reduces isosmotic fluid secretion by
CC       inhibiting electroneutral and non-conductive transport pathways.
CC       Reverses the stimulatory effect of diuretic hormone I.
CC       {ECO:0000269|PubMed:11756661, ECO:0000269|PubMed:11893763,
CC       ECO:0000269|PubMed:15235016}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=1541.58; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11756661};
CC   -!- SIMILARITY: To T.molitor cuticular protein LPCP29 C-terminal region.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; NAS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Neuropeptide; Secreted.
FT   PEPTIDE         1..14
FT                   /note="Antidiuretic factor A"
FT                   /id="PRO_0000044103"
SQ   SEQUENCE   14 AA;  1543 MW;  F49C91A3F16E43D1 CRC64;
     VVNTPGHAVS YHVY