ID   ADFB_TENMO              Reviewed;          13 AA.
AC   P83109;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 1.
DT   02-JUN-2021, entry version 32.
DE   RecName: Full=Antidiuretic factor B;
DE            Short=ADFb;
OS   Tenebrio molitor (Yellow mealworm beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrio.
OX   NCBI_TaxID=7067 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND
RP   SYNTHESIS.
RC   TISSUE=Head;
RX   PubMed=12576082; DOI=10.1016/s0196-9781(02)00273-5;
RA   Eigenheer R.A., Wiehart U.M., Nicolson S.W., Schoofs L., Schegg K.M.,
RA   Hull J.J., Schooley D.A.;
RT   "Isolation, identification and localization of a second beetle antidiuretic
RT   peptide.";
RL   Peptides 24:27-34(2003).
CC   -!- FUNCTION: Inhibitor of fluid secretion by Malpighian tubules. Uses cGMP
CC       as second messenger. May function as an antidiuretic hormone.
CC       {ECO:0000269|PubMed:12576082}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain. Appears to be mainly expressed in two pairs
CC       of bilaterally symmetrical cells in the protocerebrum.
CC       {ECO:0000269|PubMed:12576082}.
CC   -!- MASS SPECTROMETRY: Mass=1560.33; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:12576082};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Neuropeptide; Secreted.
FT   PEPTIDE         1..13
FT                   /note="Antidiuretic factor B"
FT                   /id="PRO_0000044104"
SQ   SEQUENCE   13 AA;  1562 MW;  0240A4504B8A632B CRC64;
     YDDGSYKPHI YGF