位置:首页 > 蛋白库 > DSC2_MOUSE
DSC2_MOUSE
ID   DSC2_MOUSE              Reviewed;         902 AA.
AC   P55292; Q64734;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Desmocollin-2;
DE   AltName: Full=Epithelial type 2 desmocollin;
DE   Flags: Precursor;
GN   Name=Dsc2; Synonyms=Dsc3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=7711832; DOI=10.3109/09687689409160432;
RA   Lorimer J.E., Hall L.S., Clarke J.P., Collins J.E., Fleming T.P.,
RA   Garrod D.R.;
RT   "Cloning, sequence analysis and expression pattern of mouse desmocollin 2
RT   (DSC2), a cadherin-like adhesion molecule.";
RL   Mol. Membr. Biol. 11:229-236(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 344-637.
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=7959727; DOI=10.1006/geno.1994.1309;
RA   Buxton R.S., Wheeler G.N., Pidsley S.C., Marsden M.D., Adams M.J.,
RA   Jenkins N.A., Gilbert D.J., Copeland N.G.;
RT   "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in
RT   the proximal region of chromosome 18.";
RL   Genomics 21:510-516(1994).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, and Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Component of intercellular desmosome junctions. Involved in
CC       the interaction of plaque proteins and intermediate filaments mediating
CC       cell-cell adhesion. May contribute to epidermal cell positioning
CC       (stratification) by mediating differential adhesiveness between cells
CC       that express different isoforms.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein. Cell junction, desmosome.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2A;
CC         IsoId=P55292-1; Sequence=Displayed;
CC       Name=2B;
CC         IsoId=P55292-2; Sequence=VSP_000659, VSP_000660;
CC   -!- TISSUE SPECIFICITY: In all epithelia tested and heart.
CC   -!- DOMAIN: Calcium may be bound by the cadherin-like repeats.
CC       {ECO:0000305}.
CC   -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC       cadherin domain and rigidify the connections, imparting a strong
CC       curvature to the full-length ectodomain. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L33779; AAA79177.1; -; mRNA.
DR   EMBL; L33779; AAA79176.1; -; mRNA.
DR   EMBL; X73885; CAA52089.1; -; mRNA.
DR   CCDS; CCDS29077.1; -. [P55292-2]
DR   CCDS; CCDS84361.1; -. [P55292-1]
DR   PIR; A54742; A54742.
DR   RefSeq; NP_001304294.1; NM_001317365.1. [P55292-1]
DR   RefSeq; NP_038533.1; NM_013505.4. [P55292-2]
DR   AlphaFoldDB; P55292; -.
DR   SMR; P55292; -.
DR   BioGRID; 199319; 3.
DR   STRING; 10090.ENSMUSP00000042905; -.
DR   GlyGen; P55292; 4 sites.
DR   iPTMnet; P55292; -.
DR   PhosphoSitePlus; P55292; -.
DR   MaxQB; P55292; -.
DR   PaxDb; P55292; -.
DR   PeptideAtlas; P55292; -.
DR   PRIDE; P55292; -.
DR   ProteomicsDB; 277407; -. [P55292-1]
DR   ProteomicsDB; 277408; -. [P55292-2]
DR   Antibodypedia; 2782; 347 antibodies from 32 providers.
DR   DNASU; 13506; -.
DR   Ensembl; ENSMUST00000039247; ENSMUSP00000042905; ENSMUSG00000024331. [P55292-2]
DR   Ensembl; ENSMUST00000075214; ENSMUSP00000074702; ENSMUSG00000024331. [P55292-1]
DR   GeneID; 13506; -.
DR   KEGG; mmu:13506; -.
DR   UCSC; uc008eec.1; mouse. [P55292-1]
DR   CTD; 1824; -.
DR   MGI; MGI:103221; Dsc2.
DR   VEuPathDB; HostDB:ENSMUSG00000024331; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT01030000234624; -.
DR   HOGENOM; CLU_005284_0_2_1; -.
DR   InParanoid; P55292; -.
DR   OMA; LCNCITE; -.
DR   PhylomeDB; P55292; -.
DR   TreeFam; TF316817; -.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR   BioGRID-ORCS; 13506; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Dsc2; mouse.
DR   PRO; PR:P55292; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; P55292; protein.
DR   Bgee; ENSMUSG00000024331; Expressed in conjunctival fornix and 189 other tissues.
DR   ExpressionAtlas; P55292; baseline and differential.
DR   Genevisible; P55292; MM.
DR   GO; GO:0005912; C:adherens junction; IDA:MGI.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0030057; C:desmosome; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0014704; C:intercalated disc; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0086073; P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication; ISO:MGI.
DR   GO; GO:0086042; P:cardiac muscle cell-cardiac muscle cell adhesion; ISO:MGI.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IEP:MGI.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; ISO:MGI.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; ISO:MGI.
DR   Gene3D; 4.10.900.10; -; 1.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR009122; Desmosomal_cadherin.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF01049; Cadherin_C; 1.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   PRINTS; PR01818; DESMOCADHERN.
DR   SMART; SM00112; CA; 5.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; SSF49313; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calcium; Cell adhesion; Cell junction; Cell membrane;
KW   Cleavage on pair of basic residues; Glycoprotein; Membrane; Metal-binding;
KW   Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..135
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000003871"
FT   CHAIN           136..902
FT                   /note="Desmocollin-2"
FT                   /id="PRO_0000003872"
FT   TOPO_DOM        136..694
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        695..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        716..902
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          136..243
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          244..355
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          356..471
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          472..579
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          580..694
FT                   /note="Cadherin 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   MOD_RES         865
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02487"
FT   MOD_RES         869
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02487"
FT   MOD_RES         874
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02487"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        392
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        546
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        629
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         838..848
FT                   /note="KVQFCHTDDNQ -> ETIRGHTLIKN (in isoform 2B)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_000659"
FT   VAR_SEQ         849..902
FT                   /note="Missing (in isoform 2B)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_000660"
SQ   SEQUENCE   902 AA;  99961 MW;  E233F8CB20ACCAB0 CRC64;
     MAAVGSMRSG SPAFGLGHLL TLAILALASD ACKEVVLQVP SELPAEKFVG RVNLMDCLKS
     ADIVHLSDPD FQVLEDGSVY TTSSVVLSSG QRSFTIWLFS TDSQEEREIS VHLEGPVEVL
     NKRPHTEKVL SRAKRRWAPI PCSMLENSLG PFPLFLQQIQ SDTAQNYTIY YSIRGPGVDK
     EPLNLFYVER DTGNLYCTGR VDREQYESFE LTAFATTPDG YTPEYPLPLL IKIEDENDNY
     PIFTQKLYSF TVQENSRIGS IVGEVCATDL DEPDTMHTRL RYSILEQSPS PPMLFTMHPS
     TGVITTTSAQ LDRELIDKYQ LLIKVQDMDG QYFGLHTTAK CIITIEDVND NLPTFTRTTY
     VTSVEENTVN VEILRLTVQD KDLVNSPNWR ANYTILKGNE NGNFKIVTDP KTNEGILCVI
     KPLDYEERQQ VTLQIGVVNE APYTREASSK SPMSTATVTV TVTNQDEGPE CIPPMQTVRI
     QENVPVGTRN DGYKAYDPET RSSSGIRYRK LSDPRGWVTV NEDSGSITIF RALDREAETV
     RNGIYNITVL ALDADGRSCT GTLGIILEDV NDNGPFIPKQ TVVICKATMS SAEIVAVDLD
     DPVNGPPFDF SLESSDSEVQ RMWRLTRIND TAARLSYQND PSFGSYAVPI RVTDRLGLSS
     VTTLNVLVCD CITESDCTLR SGERTGYADV RLGPWAILAI LLGIALLFCI LFTLVCSVSR
     ASKQQKILPD DLAQQNLIVS NTEAPGDDKV YSTNGLTTQT MGASGQTAFT TMGTGVKSGG
     QETIEMVKGG QQTLDSRRGA GYHHHTLDPC RGGHVEVDNY RHTYSEWYNF IQPRLGDKVQ
     FCHTDDNQKL AQDYVLTYNY EGKGSAAGSV GCCSDLQEED GLEFLDHLEP KFRTLAEVCA
     KR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024