ID   DSCR4_HUMAN             Reviewed;         118 AA.
AC   P56555; Q4VB31;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Down syndrome critical region protein 4;
DE   AltName: Full=Down syndrome critical region protein B;
GN   Name=DSCR4; Synonyms=DCRB, DSCRB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=9455479; DOI=10.1093/dnares/4.5.321;
RA   Nakamura A., Hattori M., Sakaki Y.;
RT   "A novel gene isolated from human placenta located in Down syndrome
RT   critical region on chromosome 21.";
RL   DNA Res. 4:321-324(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- TISSUE SPECIFICITY: Mainly expressed in placenta.
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DR   EMBL; AB000099; BAA25877.1; -; mRNA.
DR   EMBL; BC069729; AAH69729.1; -; mRNA.
DR   EMBL; BC096162; AAH96162.1; -; mRNA.
DR   EMBL; BC096163; AAH96163.1; -; mRNA.
DR   EMBL; BC096164; AAH96164.1; -; mRNA.
DR   RefSeq; NP_005858.1; NM_005867.3.
DR   AlphaFoldDB; P56555; -.
DR   BioGRID; 115570; 6.
DR   IntAct; P56555; 3.
DR   STRING; 9606.ENSP00000328676; -.
DR   iPTMnet; P56555; -.
DR   PhosphoSitePlus; P56555; -.
DR   BioMuta; DSCR4; -.
DR   PaxDb; P56555; -.
DR   PRIDE; P56555; -.
DR   ProteomicsDB; 56925; -.
DR   DNASU; 10281; -.
DR   UCSC; uc002ywp.3; human.
DR   GeneCards; DSCR4; -.
DR   HGNC; HGNC:3045; DSCR4.
DR   MIM; 604829; gene.
DR   neXtProt; NX_P56555; -.
DR   PharmGKB; PA27497; -.
DR   eggNOG; ENOG502TEH5; Eukaryota.
DR   HOGENOM; CLU_2084115_0_0_1; -.
DR   InParanoid; P56555; -.
DR   PathwayCommons; P56555; -.
DR   SignaLink; P56555; -.
DR   BioGRID-ORCS; 10281; 368 hits in 1070 CRISPR screens.
DR   ChiTaRS; DSCR4; human.
DR   GenomeRNAi; 10281; -.
DR   Pharos; P56555; Tdark.
DR   PRO; PR:P56555; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P56555; protein.
DR   Genevisible; P56555; HS.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..118
FT                   /note="Down syndrome critical region protein 4"
FT                   /id="PRO_0000080019"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   118 AA;  12955 MW;  97CE8D8A85F447BF CRC64;
     MSLIILTRDD EPRIFTPDSD AASPALHSTS PLPDPASASP LHREEKILPK VCNIVSCLSF
     SLPASPTDSG LASPTIITRE GQQFWAKCLI WKYQLYLHGL HKKSDGRRDK QISASPST