ID   DSCR6_DANRE             Reviewed;         110 AA.
AC   Q2WG78; Q05AP9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein ripply3;
DE   AltName: Full=Down syndrome critical region protein 6 homolog;
GN   Name=ripply3; Synonyms=dscr6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:BAE53718.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16326386; DOI=10.1016/j.devcel.2005.09.021;
RA   Kawamura A., Koshida S., Hijikata H., Ohbayashi A., Kondoh H., Takada S.;
RT   "Groucho-associated transcriptional repressor ripply1 is required for
RT   proper transition from the presomitic mesoderm to somites.";
RL   Dev. Cell 9:735-744(2005).
RN   [2] {ECO:0000312|EMBL:AAI24089.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAI24089.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcriptional regulator involved in developmental
CC       processes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- DOMAIN: The Ripply homology domain and the WRPW motif are both
CC       necessary for its transcriptional corepressor activity on the
CC       transcription activator TBX1. {ECO:0000250}.
CC   -!- DOMAIN: The WRPW motif is required for binding to tle/groucho proteins.
CC       {ECO:0000250|UniProtKB:Q2WG80}.
CC   -!- SIMILARITY: Belongs to the ripply family. {ECO:0000305}.
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DR   EMBL; AB212221; BAE53718.1; -; mRNA.
DR   EMBL; BC124088; AAI24089.1; -; mRNA.
DR   RefSeq; NP_001034199.2; NM_001039110.2.
DR   AlphaFoldDB; Q2WG78; -.
DR   STRING; 7955.ENSDARP00000053701; -.
DR   PaxDb; Q2WG78; -.
DR   Ensembl; ENSDART00000053702; ENSDARP00000053701; ENSDARG00000036974.
DR   GeneID; 654448; -.
DR   KEGG; dre:654448; -.
DR   CTD; 53820; -.
DR   ZFIN; ZDB-GENE-060113-3; ripply3.
DR   eggNOG; ENOG502S482; Eukaryota.
DR   GeneTree; ENSGT00730000111429; -.
DR   HOGENOM; CLU_117697_1_0_1; -.
DR   InParanoid; Q2WG78; -.
DR   OMA; FYNDEDS; -.
DR   OrthoDB; 1549120at2759; -.
DR   PhylomeDB; Q2WG78; -.
DR   PRO; PR:Q2WG78; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000036974; Expressed in early embryo and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; ISO:ZFIN.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0003139; P:secondary heart field specification; IMP:ZFIN.
DR   InterPro; IPR028127; Ripply_fam.
DR   PANTHER; PTHR16770; PTHR16770; 1.
DR   Pfam; PF14998; Ripply; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..110
FT                   /note="Protein ripply3"
FT                   /id="PRO_0000307764"
FT   REGION          50..85
FT                   /note="Ripply homology domain"
FT                   /evidence="ECO:0000255"
FT   REGION          87..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           18..21
FT                   /note="WRPW motif"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        25
FT                   /note="P -> A (in Ref. 2; AAI24089)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   110 AA;  12477 MW;  1FBD8DD11D116246 CRC64;
     MLPVCVDADQ ALRCSVLWRP WSLSPTEARG HKTLAGGVRS ARPSGGVFHH PVRLFLPRSR
     MQEYLSRLGS SVLASFPVQA TLHFYNDEDS SSEEEEDEEH ANTRCRLWRP