ID   DSCR6_XENTR             Reviewed;         170 AA.
AC   B1H3B4;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Protein ripply3 {ECO:0000250|UniProtKB:B7XDF1};
DE   AltName: Full=Down syndrome critical region protein 6 homolog;
GN   Name=dscr6 {ECO:0000312|Xenbase:XB-GENE-6257661};
GN   Synonyms=ripply3 {ECO:0000250|UniProtKB:B7XDF1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI61333.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole {ECO:0000312|EMBL:AAI61333.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional corepressor. Negative regulator of
CC       the transcriptional activity of tbx1 that plays a key role in
CC       pharyngeal development. Plays a role in the formation of the
CC       anteroposterior (AP) axis during embryonic development; required to
CC       establish the posterolateral border of the pre-placodal ectoderm (PPE)
CC       acting downstream of the retinoic acid receptor (RAR) signaling (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with tbx1 and tle4/grg4.
CC       {ECO:0000250|UniProtKB:B7XDF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B7XDF1}.
CC   -!- DOMAIN: The Ripply homology domain and the WRPW motif are both
CC       necessary for its transcriptional corepressor activity on the
CC       transcription activator tbx1. {ECO:0000250}.
CC   -!- DOMAIN: The WRPW motif is required for binding to tle/groucho proteins.
CC       {ECO:0000250|UniProtKB:Q25QX6}.
CC   -!- SIMILARITY: Belongs to the ripply family. {ECO:0000255}.
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DR   EMBL; BC161333; AAI61333.1; -; mRNA.
DR   RefSeq; NP_001120477.1; NM_001127005.1.
DR   AlphaFoldDB; B1H3B4; -.
DR   PaxDb; B1H3B4; -.
DR   GeneID; 100145593; -.
DR   KEGG; xtr:100145593; -.
DR   CTD; 53820; -.
DR   Xenbase; XB-GENE-6257661; ripply3.
DR   eggNOG; ENOG502S482; Eukaryota.
DR   InParanoid; B1H3B4; -.
DR   OrthoDB; 1549120at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
DR   GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR   GO; GO:0060788; P:ectodermal placode formation; ISS:UniProtKB.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR028127; Ripply_fam.
DR   PANTHER; PTHR16770; PTHR16770; 1.
DR   Pfam; PF14998; Ripply; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..170
FT                   /note="Protein ripply3"
FT                   /id="PRO_0000401113"
FT   REGION          79..114
FT                   /note="Ripply homology domain"
FT                   /evidence="ECO:0000255"
FT   REGION          143..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           40..43
FT                   /note="WRPW motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   170 AA;  19132 MW;  A0413D7BE323BDBA CRC64;
     MDSSQYRLKA TLTQLCLCSR GVRNVTSEHP EQQDSSLTLW RPWLLRAGDR ELDGQQRRLG
     EADGDHRNTG PKGALGFQHP VRLYMPKSKT SEYLQHMGKK VLANFPVQAT IHFYNDDSDS
     EEEEEDDEME FYNYYQNCAA NGVNSSRGSG DNYSVPGGPK RNISSHTGSA