ADGB_MOUSE
ID ADGB_MOUSE Reviewed; 1657 AA.
AC G3UZ78; Q8C5C7;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Androglobin;
DE AltName: Full=Calpain-7-like protein;
GN Name=Adgb; Synonyms=Capn7l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=22115833; DOI=10.1093/molbev/msr246;
RA Hoogewijs D., Ebner B., Germani F., Hoffmann F.G., Fabrizius A., Moens L.,
RA Burmester T., Dewilde S., Storz J.F., Vinogradov S.N., Hankeln T.;
RT "Androglobin: a chimeric globin in metazoans that is preferentially
RT expressed in mammalian testes.";
RL Mol. Biol. Evol. 29:1105-1114(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=G3UZ78-1; Sequence=Displayed;
CC Name=2;
CC IsoId=G3UZ78-2; Sequence=VSP_042575, VSP_042576, VSP_042577,
CC VSP_042578;
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis and lung. Weakly
CC expressed in heart, brain, spleen, kidney and tongue.
CC {ECO:0000269|PubMed:22115833}.
CC -!- SIMILARITY: Belongs to the peptidase C2 family. {ECO:0000305}.
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DR EMBL; AK078911; BAC37454.1; -; mRNA.
DR EMBL; AC153567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC159380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3UZ78; -.
DR STRING; 10090.ENSMUSP00000045452; -.
DR iPTMnet; G3UZ78; -.
DR PhosphoSitePlus; G3UZ78; -.
DR MaxQB; G3UZ78; -.
DR PaxDb; G3UZ78; -.
DR PRIDE; G3UZ78; -.
DR ProteomicsDB; 296181; -. [G3UZ78-1]
DR ProteomicsDB; 296182; -. [G3UZ78-2]
DR Antibodypedia; 50988; 17 antibodies from 9 providers.
DR Ensembl; ENSMUST00000045328; ENSMUSP00000045452; ENSMUSG00000050994. [G3UZ78-2]
DR Ensembl; ENSMUST00000172530; ENSMUSP00000134378; ENSMUSG00000050994. [G3UZ78-1]
DR UCSC; uc007eje.2; mouse. [G3UZ78-1]
DR UCSC; uc007ejf.1; mouse. [G3UZ78-2]
DR MGI; MGI:3605549; Adgb.
DR VEuPathDB; HostDB:ENSMUSG00000050994; -.
DR eggNOG; KOG0045; Eukaryota.
DR GeneTree; ENSGT00390000014904; -.
DR HOGENOM; CLU_776048_0_0_1; -.
DR InParanoid; G3UZ78; -.
DR TreeFam; TF329120; -.
DR ChiTaRS; Adgb; mouse.
DR PRO; PR:G3UZ78; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; G3UZ78; protein.
DR Bgee; ENSMUSG00000050994; Expressed in spermatid and 36 other tissues.
DR ExpressionAtlas; G3UZ78; baseline and differential.
DR Genevisible; G3UZ78; MM.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR Pfam; PF00648; Peptidase_C2; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1657
FT /note="Androglobin"
FT /id="PRO_0000416257"
FT DOMAIN 70..402
FT /note="Calpain catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00239"
FT DOMAIN 905..934
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1184..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1585..1640
FT /evidence="ECO:0000255"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1340..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..398
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042575"
FT VAR_SEQ 399..408
FT /note="QYSMQSLSEC -> MCAEDAEWKG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042576"
FT VAR_SEQ 746..754
FT /note="RHMLLFNAY -> YGLTSCFLV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042577"
FT VAR_SEQ 755..1657
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042578"
SQ SEQUENCE 1657 AA; 188556 MW; 6BE3AF391A0B5880 CRC64;
MASKQAKRKE VHRINSAHGS DKSKDLYHFG SNVPPGSFEQ KKGKFPIWPE WSEADINAEK
WDAGKGGKEK DKTAKSPIFH FFEDPEGKIE LPQSLKVFSW KRPQDFIFSR TPVVVKNEIT
FDLFSPNEHL LCSELMRWII SEIYAVWKIF NGGILSNYHK GNLGELPILP WKPWEHIYSL
CKAVKGHVPL FNSYGKYVVK LYWMGCWRKI TVDDFLPFDE ENNLLLPATS YEFELWPMLL
SKAIIKLANV DVHVAHRREL GELTVIHALT GWLPEVIPLH PAYVDRVWEL LKEILPEFKL
TEEPSSESKI TTIDNKLKEA TKENKDGKDG KNGKDLKDGK DMKDGKDGKD GKDGKDGKDG
KDEKADARDL GKKNKKDGEK EKEKFKFSLH GSRPSSDVQY SMQSLSECSS AIQLPHMVVY
ATFTPLYLFE NKIFSLEKMA NSAEKLREYG LSHICSHPVL VTRSRSCPLV SPPKPPPLPA
WKLIRHKKET VITDEAQDAV PKKPEQFLEI SSPFLNYRMT PFTIPTETHF VQSVIKKGTP
LGSSLPPLVE NDLVASTSQG EMSIVNGNQS QGNIALQITL GKDEPSEPAL ADFHQLEATS
LDRDLISLTT ATLDKSQEEL AINEGVAKEI WLDFEDFCVC FHHIYIFHKP HSYCLNFQKS
EFKFVEERVP YYLFVDSLKP IELLVCFSAL VRWGESGALT KDSPPVEPGL LTAEAITWKS
LKPLSVVLRI HTYATKASVV RLPAGRHMLL FNAYSPVGHA IHVCSMTTFV IGDEDIVLPN
FEPESYRFTE QSIIIMKAIG NVIANFKDKG KLPAALRDLQ AAHYPIPLNN KELTAQHFRV
FHISLWRLMK KSQVAKPPSN FKFAFRAMVF DTDLLDSFSE DVSLAEWVDL KYSTPINEKE
YTSEEIAAAV KIQSMWKGCY VRLLMKARKP ETKENVTVAD TLQKIWAVLE MNLEQYALSL
LRLMFKSKCK SMESYPCYQD EETKLAFADH TVNYADQPPN SWFIVFREIF LVPQDMIILP
KVYTTLPICI LHVINNDTLE QVPKVFQKVV PFLYTKNKKG YTFVAEAYTG DTFVSGARWK
LRLIGSYNPL PFLARDSPCN TFSIKEIRDY YIPNDRKILF RYSIKVTVAQ SITIQVRTSK
PDTFIKLQVL ESEEVITSTV GKGQAVIPAF YFLGNEKALS SQSSKQVLLS HPSPKKDPEV
LTKKKSGQPG QKSFKGRSGG GLTDTGMPLL EEEILNIPTL EENSSTPQQC YKYIIQCLVL
FNSWPLNETQ LTFVQALKDM EKMDIKEKHE EPAPMGSPDS HAVSEGQKSV GVPKTTRKGK
EKSAEKEKLA KEKQAPRFEP QQVQMPTAVH SQQEDPNKPY WILRLVSEHT DSDYVDVKKD
TERADEIRAM KQAWETTEPG RAIKAAQARL KYLTQFIKKP VTTDTTTSAP SPETLSVSQS
QTKSSEEGEL DTGKYADIKE LPPNAAGSVL WKKWQMTKTI TSLTKFTSSE SVPKEEPPQK
EIPVVRQRSP TILETSPQQI RKALEFLDFS HYVRKTAAEA VLQTEELNKQ QAMQKAEEIH
QFRQHRSRIL SIRDIDQEER FKQKDEVLEM YGEMRDSVDE ARQKILDIRE VYRNKLLEAE
RLRMEALAAQ EAAVKIEIEK KSPASDSQKK KKVGKKK
