DSDC_ECOLI
ID DSDC_ECOLI Reviewed; 311 AA.
AC P46068; P77443;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=HTH-type transcriptional regulator DsdC;
DE AltName: Full=D-serine deaminase activator;
GN Name=dsdC {ECO:0000303|PubMed:7592420}; OrderedLocusNames=b2364, JW2361;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION BY D-SERINE, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=K12;
RX PubMed=7592420; DOI=10.1128/jb.177.22.6456-6461.1995;
RA Noerregaard-Madsen M., McFall E., Valentin-Hansen P.;
RT "Organization and transcriptional regulation of the Escherichia coli K-12
RT D-serine tolerance locus.";
RL J. Bacteriol. 177:6456-6461(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-53.
RC STRAIN=K12;
RA Brannigan J.A.;
RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the expression of the dsdX-dsdA operon.
CC {ECO:0000269|PubMed:7592420}.
CC -!- INDUCTION: By growth in D-serine. {ECO:0000269|PubMed:7592420}.
CC -!- DISRUPTION PHENOTYPE: No longer induces the dsdX-dsdA operon.
CC {ECO:0000269|PubMed:7592420}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; X91821; CAA62931.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75423.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16224.1; -; Genomic_DNA.
DR EMBL; X86379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A65010; A65010.
DR RefSeq; NP_416865.1; NC_000913.3.
DR RefSeq; WP_001326971.1; NZ_LN832404.1.
DR AlphaFoldDB; P46068; -.
DR SMR; P46068; -.
DR BioGRID; 4260553; 5.
DR DIP; DIP-9480N; -.
DR IntAct; P46068; 5.
DR STRING; 511145.b2364; -.
DR PaxDb; P46068; -.
DR PRIDE; P46068; -.
DR EnsemblBacteria; AAC75423; AAC75423; b2364.
DR EnsemblBacteria; BAA16224; BAA16224; BAA16224.
DR GeneID; 948828; -.
DR KEGG; ecj:JW2361; -.
DR KEGG; eco:b2364; -.
DR PATRIC; fig|1411691.4.peg.4365; -.
DR EchoBASE; EB2953; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_37_0_6; -.
DR InParanoid; P46068; -.
DR OMA; WHAHLAI; -.
DR PhylomeDB; P46068; -.
DR BioCyc; EcoCyc:PD00297; -.
DR PRO; PR:P46068; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011781; DsdC.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02036; dsdC; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..311
FT /note="HTH-type transcriptional regulator DsdC"
FT /id="PRO_0000105621"
FT DOMAIN 15..72
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 32..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT CONFLICT 159
FT /note="A -> R (in Ref. 1; CAA62931)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 35332 MW; 0335B060CF5DB3BB CRC64;
MEPLREIRNR LLNGWQLSKM HTFEVAARHQ SFALAAEELS LSPSAVSHRI NQLEEELGIQ
LFVRSHRKVE LTHEGKRVYW ALKSSLDTLN QEILDIKNQE LSGTLTLYSR PSIAQCWLVP
ALGDFTRRYP SISLTVLTGN DNVNLQRAGI DLAIYFDDAP SAQLTHHFLM DEEILPVCSP
EYAQRHALTN TVINLCHCTL LHDRQAWSND SGTDEWHSWA QHYAVNLPTS SGIGFDRSDL
AVIAAMNHIG VAMGRKRLVQ KRLASGELVA PFGDMTVKCH QHYYITTLPG RQWPKIEAFI
IWLREQVKTT S
