ID   DSE1_NICBE              Reviewed;         375 AA.
AC   F1DLK1;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Protein DECREASED SIZE EXCLUSION LIMIT 1 {ECO:0000303|PubMed:22411811};
DE            Short=NbDSE1 {ECO:0000303|PubMed:22411811};
GN   Name=DSE1 {ECO:0000303|PubMed:22411811};
OS   Nicotiana benthamiana.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4100 {ECO:0000312|EMBL:ADX87418.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22411811; DOI=10.1073/pnas.1202919109;
RA   Xu M., Cho E., Burch-Smith T.M., Zambryski P.C.;
RT   "Plasmodesmata formation and cell-to-cell transport are reduced in
RT   decreased size exclusion limit 1 during embryogenesis in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:5098-5103(2012).
CC   -!- FUNCTION: Involved in the formation of X-, Y-shaped and twinned
CC       plasmodesmata (PD), thus modelating PD size exclusion limit and
CC       regulating cell-to-cell transport (PubMed:22411811). Cell cycle
CC       checkpoint regulator that monitors and responds to DNA damage such as
CC       DNA cross-links, and triggers the halt of the cell cycle progression in
CC       the presence of DNA cross-linking agents. Mediates the active process
CC       of aluminum- (Al) dependent root growth inhibition and thus is required
CC       for response to Al toxicity. Essential for signal transduction and
CC       development of both male and female organs (By similarity).
CC       {ECO:0000250|UniProtKB:Q3MV14, ECO:0000269|PubMed:22411811}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3MV14}. Nucleus
CC       {ECO:0000250|UniProtKB:Q3MV14}.
CC   -!- DISRUPTION PHENOTYPE: Reduced plasmodesmata (PD)-mediated horizontal
CC       and vertical cell-to-cell transport in leaves.
CC       {ECO:0000269|PubMed:22411811}.
CC   -!- SIMILARITY: Belongs to the plant DSE1 protein family. {ECO:0000305}.
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DR   EMBL; HQ873433; ADX87418.1; -; mRNA.
DR   AlphaFoldDB; F1DLK1; -.
DR   SMR; F1DLK1; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0048481; P:plant ovule development; ISS:UniProtKB.
DR   GO; GO:0009663; P:plasmodesma organization; ISS:UniProtKB.
DR   GO; GO:0010497; P:plasmodesmata-mediated intercellular transport; IMP:UniProtKB.
DR   GO; GO:0009555; P:pollen development; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0006282; P:regulation of DNA repair; ISS:UniProtKB.
DR   GO; GO:0010044; P:response to aluminum ion; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Developmental protein; DNA damage; Nucleus; Repeat;
KW   WD repeat.
FT   CHAIN           1..375
FT                   /note="Protein DECREASED SIZE EXCLUSION LIMIT 1"
FT                   /id="PRO_0000432851"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          59..100
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          144..189
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          203..247
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          251..290
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          297..338
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          339..375
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   375 AA;  40588 MW;  9880FDE6A22AC510 CRC64;
     MSKRPAPDPV SVLRGHRASV ADICFHPSNS ILFSGSTDGE LRIWNTVQYR TVSSAWVHSA
     AHGIICVAAS PVLGDNKVIS QGRDGTVKCW DFGGGGLSRT PLLTIKTNSY HFCKLSIAKS
     PSEAMKIDDL EVNEIVDGMQ REEQGDQPTD SIKFKGKELI EGPKYVAIAG EQASVVEIWD
     VNTAERIAQL PHSSGSPSNQ TPNQRGMCMA VQAFLPSESQ GLLSIMAGYE DGSIAWWDLR
     NLGVPLTSVK FHSEPVLSLC IDGSCKGGLS GAADEKILMF ALDHSMGSCL IRKEIVLERP
     GIAGTSIRPD GKIAATAGWD HRVRIYNYRK GKPLAILKYH NATCNTVSFS ADSKLLASAS
     EDTTVALWEL YLPRT