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DSE1_YEAST
ID   DSE1_YEAST              Reviewed;         573 AA.
AC   P40077; D3DM30;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=Protein DSE1;
DE   AltName: Full=Daughter-specific expression protein 1;
GN   Name=DSE1; OrderedLocusNames=YER124C; ORFNames=SYGP-ORF48;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   INDUCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11747810; DOI=10.1016/s0092-8674(01)00596-7;
RA   Colman-Lerner A., Chin T.E., Brent R.;
RT   "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce
RT   asymmetric cell fates.";
RL   Cell 107:739-750(2001).
RN   [4]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=11309124; DOI=10.1046/j.1365-2958.2001.02388.x;
RA   Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.;
RT   "Overlapping and distinct roles of the duplicated yeast transcription
RT   factors Ace2p and Swi5p.";
RL   Mol. Microbiol. 40:422-432(2001).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   INDUCTION.
RX   PubMed=14709718; DOI=10.1242/jcs.00880;
RA   Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.;
RT   "Swm1p subunit of the APC/cyclosome is required for activation of the
RT   daughter-specific gene expression program mediated by Ace2p during growth
RT   at high temperature in Saccharomyces cerevisiae.";
RL   J. Cell Sci. 117:545-557(2004).
RN   [8]
RP   INDUCTION.
RX   PubMed=16820445; DOI=10.1128/aem.03050-05;
RA   Purevdorj-Gage B., Sheehan K.B., Hyman L.E.;
RT   "Effects of low-shear modeled microgravity on cell function, gene
RT   expression, and phenotype in Saccharomyces cerevisiae.";
RL   Appl. Environ. Microbiol. 72:4569-4575(2006).
RN   [9]
RP   UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-553, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22106047; DOI=10.1002/pmic.201100166;
RA   Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT   "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL   Proteomics 12:236-240(2012).
CC   -!- FUNCTION: Involved in cell wall metabolism and required for the
CC       separation of the mother and daughter cells.
CC       {ECO:0000269|PubMed:11309124}.
CC   -!- INTERACTION:
CC       P40077; P39969: BOI2; NbExp=3; IntAct=EBI-22676, EBI-3727;
CC   -!- SUBCELLULAR LOCATION: Bud neck {ECO:0000269|PubMed:14562095}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in daughter cells.
CC       {ECO:0000269|PubMed:11747810}.
CC   -!- INDUCTION: Expressed periodically during cell division. Requires ACE2,
CC       CBK1, MOB2 and SWI5. Expression is also increased under microgravity
CC       conditions. {ECO:0000269|PubMed:11309124, ECO:0000269|PubMed:11747810,
CC       ECO:0000269|PubMed:14709718, ECO:0000269|PubMed:16820445}.
CC   -!- MISCELLANEOUS: Present with 3080 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the WD repeat DSE1 family. {ECO:0000305}.
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DR   EMBL; U18916; AAC03222.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07784.1; -; Genomic_DNA.
DR   PIR; S50627; S50627.
DR   RefSeq; NP_011050.3; NM_001179014.3.
DR   AlphaFoldDB; P40077; -.
DR   BioGRID; 36868; 92.
DR   DIP; DIP-2585N; -.
DR   IntAct; P40077; 5.
DR   MINT; P40077; -.
DR   STRING; 4932.YER124C; -.
DR   iPTMnet; P40077; -.
DR   MaxQB; P40077; -.
DR   PaxDb; P40077; -.
DR   PRIDE; P40077; -.
DR   EnsemblFungi; YER124C_mRNA; YER124C; YER124C.
DR   GeneID; 856861; -.
DR   KEGG; sce:YER124C; -.
DR   SGD; S000000926; DSE1.
DR   VEuPathDB; FungiDB:YER124C; -.
DR   eggNOG; ENOG502QTST; Eukaryota.
DR   HOGENOM; CLU_033098_0_0_1; -.
DR   InParanoid; P40077; -.
DR   OMA; QCGNIIV; -.
DR   BioCyc; YEAST:G3O-30287-MON; -.
DR   PRO; PR:P40077; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40077; protein.
DR   GO; GO:0005935; C:cellular bud neck; HDA:SGD.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:SGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
DR   GO; GO:0010969; P:regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.
DR   GO; GO:0000920; P:septum digestion after cytokinesis; IMP:SGD.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell wall biogenesis/degradation;
KW   Isopeptide bond; Reference proteome; Repeat; Ubl conjugation; WD repeat.
FT   CHAIN           1..573
FT                   /note="Protein DSE1"
FT                   /id="PRO_0000202647"
FT   REPEAT          144..185
FT                   /note="WD 1"
FT   REPEAT          315..351
FT                   /note="WD 2"
FT   REPEAT          356..395
FT                   /note="WD 3"
FT   REPEAT          397..448
FT                   /note="WD 4"
FT   REGION          500..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        553
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0007744|PubMed:22106047"
SQ   SEQUENCE   573 AA;  63999 MW;  D5FE871E7C76B260 CRC64;
     MQDTKYYEPT NIFRQPAINI KKRSDKKRIL QSMMTLSTYK KTWQNNTSKM NSPILRKASD
     NFNDYYTTKK LKSDYWKLYG VDESELSIPS DMSIVDNILL VSTMNEKDNL KLFEISAEKK
     LKELQTITVP GKPITCICLL PMVDFPPQIF PSSQINPNHN QLILTGHQDG IVNLIATSTY
     KGCAKIIKRF NHNKFLKSTV STSIPILEIT PKTAPILKVS PWNKTGFVSL LNDSLFIYDL
     KSNLDCIKTP IFLQSYPGIN SFAVNEFHDP FLLALVGSKF GPNGISLLDL RTNLYIPDIL
     DNSISAGCGK DHLQRKNTSL DCVWISNHHV AQSLNDKIQI WDIQSCDGKP VCELYAKKGY
     IESLKFNENT GALYSSDDQG FVICWDLQNL QNMKYGELVH GFNSISLDSE SELLLTKQVF
     QCGNIIVSGM SDKNICLKSN DTKANGKGCG FLFLDMANDG SLVTLDNFCE LGLHQICQVQ
     FNVDTGKIID GNGTGKSGIS DSSMLSLSNE SDHSMTETSD DMFSNSGNWD CSSANTVSEG
     RLNDDQEDIV FTKRMYSVND VHLSGSTIDT TVV
 
 
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