DSE2_YEAST
ID DSE2_YEAST Reviewed; 325 AA.
AC P38844; D3DL92;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein DSE2;
DE AltName: Full=Daughter-specific expression protein 2;
DE Flags: Precursor;
GN Name=DSE2; OrderedLocusNames=YHR143W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP INDUCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=11747810; DOI=10.1016/s0092-8674(01)00596-7;
RA Colman-Lerner A., Chin T.E., Brent R.;
RT "Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce
RT asymmetric cell fates.";
RL Cell 107:739-750(2001).
RN [4]
RP INDUCTION, AND FUNCTION.
RX PubMed=11309124; DOI=10.1046/j.1365-2958.2001.02388.x;
RA Doolin M.-T., Johnson A.L., Johnston L.H., Butler G.;
RT "Overlapping and distinct roles of the duplicated yeast transcription
RT factors Ace2p and Swi5p.";
RL Mol. Microbiol. 40:422-432(2001).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=11935221; DOI=10.1007/s00294-001-0264-9;
RA Terashima H., Fukuchi S., Nakai K., Arisawa M., Hamada K., Yabuki N.,
RA Kitada K.;
RT "Sequence-based approach for identification of cell wall proteins in
RT Saccharomyces cerevisiae.";
RL Curr. Genet. 40:311-316(2002).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP INDUCTION.
RX PubMed=14709718; DOI=10.1242/jcs.00880;
RA Ufano S., Pablo M.E., Calzada A., del Rey F., Vazquez de Aldana C.R.;
RT "Swm1p subunit of the APC/cyclosome is required for activation of the
RT daughter-specific gene expression program mediated by Ace2p during growth
RT at high temperature in Saccharomyces cerevisiae.";
RL J. Cell Sci. 117:545-557(2004).
RN [8]
RP INDUCTION.
RX PubMed=16820445; DOI=10.1128/aem.03050-05;
RA Purevdorj-Gage B., Sheehan K.B., Hyman L.E.;
RT "Effects of low-shear modeled microgravity on cell function, gene
RT expression, and phenotype in Saccharomyces cerevisiae.";
RL Appl. Environ. Microbiol. 72:4569-4575(2006).
CC -!- FUNCTION: Involved in pseudohyphal growth, cell wall metabolism and
CC required for the separation of the mother and daughter cells.
CC {ECO:0000269|PubMed:11309124}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000269|PubMed:11935221}. Membrane {ECO:0000269|PubMed:11935221};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11935221}. Note=GPI-
CC anchored cell wall protein (GPI-CWP).
CC -!- DEVELOPMENTAL STAGE: Expressed in daughter cells.
CC {ECO:0000269|PubMed:11747810}.
CC -!- INDUCTION: Expressed periodically during cell division. Requires ACE2,
CC CBK1, MOB2 and SWI5. Expression is also increased under microgravity
CC conditions. {ECO:0000269|PubMed:11309124, ECO:0000269|PubMed:11747810,
CC ECO:0000269|PubMed:14709718, ECO:0000269|PubMed:16820445}.
CC -!- MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the DSE2 family. {ECO:0000305}.
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DR EMBL; U10397; AAB68983.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06836.1; -; Genomic_DNA.
DR PIR; S46760; S46760.
DR RefSeq; NP_012012.1; NM_001179274.1.
DR AlphaFoldDB; P38844; -.
DR BioGRID; 36576; 118.
DR IntAct; P38844; 2.
DR MINT; P38844; -.
DR STRING; 4932.YHR143W; -.
DR PaxDb; P38844; -.
DR EnsemblFungi; YHR143W_mRNA; YHR143W; YHR143W.
DR GeneID; 856546; -.
DR KEGG; sce:YHR143W; -.
DR SGD; S000001186; DSE2.
DR VEuPathDB; FungiDB:YHR143W; -.
DR eggNOG; ENOG502S41K; Eukaryota.
DR HOGENOM; CLU_1031328_0_0_1; -.
DR InParanoid; P38844; -.
DR OMA; TRVYPIT; -.
DR BioCyc; YEAST:G3O-31180-MON; -.
DR PRO; PR:P38844; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38844; protein.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IDA:SGD.
DR GO; GO:0009277; C:fungal-type cell wall; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0015926; F:glucosidase activity; ISS:SGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR GO; GO:0000920; P:septum digestion after cytokinesis; IMP:SGD.
DR InterPro; IPR026225; DSE2.
DR PRINTS; PR02066; DSEPROTEIN2.
PE 1: Evidence at protein level;
KW Cell wall; Cell wall biogenesis/degradation; Glycoprotein; GPI-anchor;
KW Lipoprotein; Membrane; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..308
FT /note="Protein DSE2"
FT /id="PRO_0000014328"
FT PROPEP 309..325
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000285355"
FT REGION 109..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 308
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000255"
SQ SEQUENCE 325 AA; 33417 MW; 72FD171D5C919A1F CRC64;
MKFNFSTIFN ILFFLFTLIE ANSNGETVKL ITSDGIVYSY AVYTKTLAPA RVVVKTISYT
TTRVYPITLA NSVVSSTTEK ITEVSTVSAS EQVSATQTNS LVSTSTVSTI SPTISSGSST
SSSSTYDIES SQSIESSGTS SATAEPSASS GFRLTSSSAF VSSTAPFSSQ LSSSSSSETS
SSSFSTSSSS APLSLTSSSS SSSSFATIIT LAPSSSKSGN SQLTLASSSS TSAVESSQTG
STIARTTSTL VPSSSVDTTS RATTSMPLES SSTQSISVSS SDGTCYVFYD DDDYYSTVYL
TNPSQSVDAA TTITSTNTIY ATVTI
