DSEL_MOUSE
ID DSEL_MOUSE Reviewed; 1207 AA.
AC Q0VBN2; B2RQ79;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Dermatan-sulfate epimerase-like protein;
DE EC=5.1.-.-;
DE Flags: Precursor;
GN Name=Dsel;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the dermatan-sulfate isomerase family.
CC {ECO:0000305}.
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DR EMBL; BC120567; AAI20568.1; -; mRNA.
DR EMBL; BC137796; AAI37797.1; -; mRNA.
DR CCDS; CCDS35688.1; -.
DR RefSeq; NP_001074785.1; NM_001081316.1.
DR RefSeq; XP_017176672.1; XM_017321183.1.
DR RefSeq; XP_017176673.1; XM_017321184.1.
DR AlphaFoldDB; Q0VBN2; -.
DR SMR; Q0VBN2; -.
DR STRING; 10090.ENSMUSP00000043570; -.
DR GlyGen; Q0VBN2; 5 sites.
DR iPTMnet; Q0VBN2; -.
DR PhosphoSitePlus; Q0VBN2; -.
DR CPTAC; non-CPTAC-3457; -.
DR PaxDb; Q0VBN2; -.
DR PRIDE; Q0VBN2; -.
DR ProteomicsDB; 277503; -.
DR Antibodypedia; 77494; 4 antibodies from 4 providers.
DR Ensembl; ENSMUST00000035462; ENSMUSP00000043570; ENSMUSG00000038702.
DR GeneID; 319901; -.
DR KEGG; mmu:319901; -.
DR UCSC; uc007chy.1; mouse.
DR CTD; 92126; -.
DR MGI; MGI:2442948; Dsel.
DR VEuPathDB; HostDB:ENSMUSG00000038702; -.
DR eggNOG; ENOG502QPWZ; Eukaryota.
DR GeneTree; ENSGT00390000006522; -.
DR HOGENOM; CLU_011348_0_0_1; -.
DR InParanoid; Q0VBN2; -.
DR OMA; WRFYLSF; -.
DR OrthoDB; 588663at2759; -.
DR PhylomeDB; Q0VBN2; -.
DR TreeFam; TF334118; -.
DR BRENDA; 5.1.3.19; 3474.
DR Reactome; R-MMU-2022923; Dermatan sulfate biosynthesis.
DR BioGRID-ORCS; 319901; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q0VBN2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q0VBN2; protein.
DR Bgee; ENSMUSG00000038702; Expressed in condyle and 211 other tissues.
DR Genevisible; Q0VBN2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0047757; F:chondroitin-glucuronate 5-epimerase activity; IMP:MGI.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0030204; P:chondroitin sulfate metabolic process; IMP:MGI.
DR GO; GO:0030205; P:dermatan sulfate metabolic process; IMP:MGI.
DR Gene3D; 1.50.10.100; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF48230; SSF48230; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Isomerase; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1207
FT /note="Dermatan-sulfate epimerase-like protein"
FT /id="PRO_0000278289"
FT TRANSMEM 761..781
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 798..818
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 661
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 683
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 869
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1207 AA; 138868 MW; B9001ED3AB323ABF CRC64;
MAFMFTEHLL FLTLMMCSFS TCEESVSNYS EWAVFTDDIQ WLKSQKIQDF KLNRRLHPNL
YFDAGDIQTL KQKSRTSHLH IFRAIKSAVT IMLSNPSYYL PPPKHAEFAA KWNEIYGNNL
PPLALYCLLC PEDKVAFEFV MEYMDRMVSY KDWLVENAPG DEVPVGHSLT GFATAFDFLY
NLLGNQRKQK YLEKIWIVTE EMYEYSKIRS WGKQLLHNHQ ATNMIALLIG ALVTGVDKGS
KANIWKQVVV DVMEKTMFLL KHIVDGSLDE GVAYGSYTSK SVTQYVFLAQ RHFNINNFDN
NWLKMHFWFY YATLLPGYQR TVGIADSNYN WFYGPESQLV FLDKFILQNG AGNWLAQQIR
KHRPKDGPMV PSTAQRWSTL HTEYIWYDPT LTPQPPVDFG TAKMHTFPNW GVVTYGGGLP
NTQTNTFVSF KSGKLGGRAV YDIVHFQPYS WIDGWRSFNP GHEHPDQNSF TFAPNGQVFV
SEALYGPKLS HLNNVLVFAP SPSSQCNQPW EGQLGECAQW LKWTGEEVGD AAGEVITAAQ
HGDRMFVSGE AVSAYSSAMR LKSVYRALLL LNSQTLLVVD HIERQETSPI NSVSAFFHNL
DIDFKYIPYK FMNRYNGAMM DVWDAHYKMF WFDHHGNSPV ANIQEAEQAA EFKKRWTQFV
NVTFHMESTI TRIAYVFYGP YVNVSSCRFI DSSSSGLQIS LHVNSTEHSV SVVTDYQNLK
SRFSYLGFGG FASVANQGQI TRFGLGTQEI VNPVRHDKVN FPFGFKFNIA VGFILCISLV
ILTFQWRFYL SFRKLMRCVL ILVIALWFIE LLDVWSTCTQ PICAKWTRTE AKANEKVMIS
EGHHVDLPNV IITSLPGSGA EILKQLFFNS SDFLYIRIPT AYMDIPETEF EIDSFVDACE
WKVSDIRSGH FHLLRGWLQS LVQDTKLHLQ NIHLHETSRS KLAQYFTTNK DKKRKLKRRE
SLQDQRSRIK GPFDRDAEYI RALRRHLVYY PSARPVLSLS SGSWTLKLHF FQEVLGTSMR
ALYIVRDPRA WIYSVLYGSK PSLYSLKNVP EHLAKLFKIE EGKSKCNSNS GYAFEYESLK
KELEISQSNA ISLLSHLWVA NTAAALRINT DLLPTNYHLV KFEDIVHFPQ KTTERIFAFL
GIPLSPASLN QMLFATSTNL FYLPYEGEIS PSNTNIWKTN LPRDEIKLIE NICWTLMDHL
GYPKFMD
