ID   DSK_DROPS               Reviewed;         139 AA.
AC   Q295C6;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Drosulfakinins {ECO:0000303|PubMed:17632121};
DE   Contains:
DE     RecName: Full=Drosulfakinin-0 {ECO:0000303|PubMed:17632121};
DE              Short=DSK-0 {ECO:0000303|PubMed:17632121};
DE   Contains:
DE     RecName: Full=Drosulfakinin-1 {ECO:0000303|PubMed:17632121};
DE     AltName: Full=Drosulfakinin I {ECO:0000303|PubMed:17632121};
DE              Short=DSK-I {ECO:0000303|PubMed:17632121};
DE   Contains:
DE     RecName: Full=Drosulfakinin-2 {ECO:0000303|PubMed:17632121};
DE     AltName: Full=Drosulfakinin II {ECO:0000303|PubMed:17632121};
DE              Short=DSK-II {ECO:0000303|PubMed:17632121};
DE   Flags: Precursor;
GN   Name=Dsk {ECO:0000250|UniProtKB:P09040}; ORFNames=GA14787;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=17632121; DOI=10.1016/j.jinsphys.2007.06.001;
RA   Palmer G.C., Tran T., Duttlinger A., Nichols R.;
RT   "The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene
RT   affects adult Drosophila melanogaster crop contractions.";
RL   J. Insect Physiol. 53:1125-1133(2007).
CC   -!- FUNCTION: Drosulfakinin-0 (DSK 0) plays diverse biological roles
CC       including regulating gut muscle contraction in adults but not in
CC       larvae. {ECO:0000250|UniProtKB:P09040}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09040}.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000255}.
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DR   EMBL; CM000070; EAL28786.2; -; Genomic_DNA.
DR   RefSeq; XP_001359636.2; XM_001359599.3.
DR   AlphaFoldDB; Q295C6; -.
DR   STRING; 7237.FBpp0281321; -.
DR   EnsemblMetazoa; FBtr0282883; FBpp0281321; FBgn0074814.
DR   GeneID; 4802776; -.
DR   KEGG; dpo:Dpse_GA14787; -.
DR   eggNOG; ENOG502SESC; Eukaryota.
DR   HOGENOM; CLU_1847224_0_0_1; -.
DR   InParanoid; Q295C6; -.
DR   OMA; FGDRRNQ; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0074814; Expressed in insect adult head.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006939; P:smooth muscle contraction; ISS:UniProtKB.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   InterPro; IPR013259; Sulfakinin.
DR   Pfam; PF08257; Sulfakinin; 2.
DR   PROSITE; PS00259; GASTRIN; 2.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW   Reference proteome; Secreted; Signal; Sulfation.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   PROPEP          36..71
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000351170"
FT   PEPTIDE         74..80
FT                   /note="Drosulfakinin-0"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000351171"
FT   PROPEP          81..109
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000351172"
FT   PEPTIDE         112..120
FT                   /note="Drosulfakinin-1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000351173"
FT   PEPTIDE         124..137
FT                   /note="Drosulfakinin-2"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000351174"
FT   MOD_RES         80
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         115
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         120
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         132
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         137
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  15743 MW;  CB7E9A4EBE268A51 CRC64;
     MGHRGMGCAH FATMAMPLWA LTFYLLVVLP VPSQTASVEV GKEERRLQDL DPKMGSEAGN
     TDGLSLARFG SRRHQRSTGF GHRVPIISRP VIPIELDLLM DNEDDRTMSK RFDDYGHMRF
     GKRGGDDQFD DYGHMRFGR