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ADH1E_HORSE
ID   ADH1E_HORSE             Reviewed;         375 AA.
AC   P00327;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 170.
DE   RecName: Full=Alcohol dehydrogenase E chain;
DE            EC=1.1.1.1;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=1712777; DOI=10.1016/s0021-9258(18)98838-1;
RA   Park D.H., Plapp B.V.;
RT   "Isoenzymes of horse liver alcohol dehydrogenase active on ethanol and
RT   steroids. cDNA cloning, expression, and comparison of active sites.";
RL   J. Biol. Chem. 266:13296-13302(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-375, AND ACETYLATION AT SER-2.
RC   TISSUE=Liver;
RX   PubMed=5466062; DOI=10.1111/j.1432-1033.1970.tb01050.x;
RA   Joernvall H.;
RT   "Horse liver alcohol dehydrogenase. On the primary structures of the
RT   isoenzymes.";
RL   Eur. J. Biochem. 16:41-49(1970).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX   PubMed=178875; DOI=10.1016/0022-2836(76)90072-3;
RA   Eklund H., Nordstroem B., Zeppezauer E., Soederlund G., Ohlsson I.,
RA   Boiwe T., Soederberg B.-O., Tapia O., Braenden C.-I., Aakeson A.;
RT   "Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4-A
RT   resolution.";
RL   J. Mol. Biol. 102:27-59(1976).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
RX   PubMed=6098306; DOI=10.1021/bi00320a014;
RA   Eklund H., Samama J.-P., Jones T.A.;
RT   "Crystallographic investigations of nicotinamide adenine dinucleotide
RT   binding to horse liver alcohol dehydrogenase.";
RL   Biochemistry 23:5982-5996(1984).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-375 IN COMPLEX WITH NAD AND
RP   ZINC, AND COFACTOR.
RX   PubMed=15299346; DOI=10.1107/s0907444994005263;
RA   Al-Karadaghi S., Cedergren-Zeppezauer E.S., Hovmoeller S., Petratos K.,
RA   Terry H., Wilson K.S.;
RT   "Refined crystal structure of liver alcohol dehydrogenase-NADH complex at
RT   1.8-A resolution.";
RL   Acta Crystallogr. D 50:793-807(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC         Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC         Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC         ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000269|PubMed:15299346};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:15299346};
CC   -!- SUBUNIT: Dimer of identical or non-identical chains of two types (E and
CC       S) coded by 2 separate genes at different loci.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Class-I subfamily. {ECO:0000305}.
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DR   EMBL; M64864; AAA30931.1; -; mRNA.
DR   PIR; A39872; DEHOAL.
DR   RefSeq; NP_001075997.1; NM_001082528.1.
DR   PDB; 1A71; X-ray; 2.00 A; A/B=2-375.
DR   PDB; 1A72; X-ray; 2.60 A; A=2-375.
DR   PDB; 1ADB; X-ray; 2.40 A; A/B=2-375.
DR   PDB; 1ADC; X-ray; 2.70 A; A/B=2-375.
DR   PDB; 1ADF; X-ray; 2.90 A; A=2-375.
DR   PDB; 1ADG; X-ray; 2.70 A; A=2-375.
DR   PDB; 1AXE; X-ray; 2.00 A; A/B=2-375.
DR   PDB; 1AXG; X-ray; 2.50 A; A/B/C/D=2-375.
DR   PDB; 1BTO; X-ray; 2.00 A; A/B/C/D=2-375.
DR   PDB; 1HET; X-ray; 1.15 A; A/B=2-375.
DR   PDB; 1HEU; X-ray; 1.15 A; A/B=2-375.
DR   PDB; 1HF3; X-ray; 1.95 A; A/B=2-375.
DR   PDB; 1HLD; X-ray; 2.10 A; A/B=2-375.
DR   PDB; 1JU9; X-ray; 2.00 A; A/B=2-375.
DR   PDB; 1LDE; X-ray; 2.50 A; A/B/C/D=2-375.
DR   PDB; 1LDY; X-ray; 2.50 A; A/B/C/D=2-375.
DR   PDB; 1MG0; X-ray; 1.80 A; A/B/C/D=2-375.
DR   PDB; 1MGO; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 1N8K; X-ray; 1.13 A; A/B=2-375.
DR   PDB; 1N92; X-ray; 1.47 A; A/B=2-375.
DR   PDB; 1P1R; X-ray; 1.57 A; A/B/C/D=2-375.
DR   PDB; 1QLH; X-ray; 2.07 A; A=2-375.
DR   PDB; 1QLJ; X-ray; 2.80 A; A=2-375.
DR   PDB; 1QV6; X-ray; 1.80 A; A/B=2-375.
DR   PDB; 1QV7; X-ray; 1.80 A; A/B=2-375.
DR   PDB; 1YE3; X-ray; 1.59 A; A=2-375.
DR   PDB; 2JHF; X-ray; 1.00 A; A/B=2-375.
DR   PDB; 2JHG; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 2OHX; X-ray; 1.80 A; A/B=2-375.
DR   PDB; 2OXI; X-ray; 2.10 A; A/B=2-375.
DR   PDB; 3BTO; X-ray; 1.66 A; A/B/C/D=2-375.
DR   PDB; 3OQ6; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 4DWV; X-ray; 1.14 A; A/B=2-375.
DR   PDB; 4DXH; X-ray; 1.12 A; A/B=2-375.
DR   PDB; 4NFH; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 4NFS; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 4NG5; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 4XD2; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 5ADH; X-ray; 2.90 A; A=2-375.
DR   PDB; 5CDG; X-ray; 1.40 A; A/B=2-375.
DR   PDB; 5CDS; X-ray; 1.40 A; A/B=2-375.
DR   PDB; 5CDT; X-ray; 1.70 A; A/B=2-375.
DR   PDB; 5CDU; X-ray; 1.60 A; A/B=2-375.
DR   PDB; 5KCP; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 5KCZ; X-ray; 1.14 A; A/B=2-375.
DR   PDB; 5KJ1; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 5KJ6; X-ray; 1.14 A; A/B=2-375.
DR   PDB; 5KJC; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 5KJE; X-ray; 1.26 A; A/B=2-375.
DR   PDB; 5KJF; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 5VJ5; X-ray; 1.90 A; A/B=2-375.
DR   PDB; 5VJG; X-ray; 1.90 A; A=2-375.
DR   PDB; 5VKR; X-ray; 1.80 A; A=2-375.
DR   PDB; 5VL0; X-ray; 1.20 A; A/B/C/D=2-375.
DR   PDB; 5VN1; X-ray; 1.25 A; A/B/C/D=2-375.
DR   PDB; 6ADH; X-ray; 2.90 A; A/B=2-375.
DR   PDB; 6CXX; X-ray; 1.26 A; A/B=2-375.
DR   PDB; 6CY3; X-ray; 2.30 A; A=2-375.
DR   PDB; 6NBB; EM; 2.90 A; A/B=2-375.
DR   PDB; 6O91; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 6OA7; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 6OWM; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 6OWP; X-ray; 1.14 A; A/B=2-375.
DR   PDB; 6XT2; X-ray; 1.55 A; A/B/C/D=2-375.
DR   PDB; 7ADH; X-ray; 3.20 A; A=2-375.
DR   PDB; 7JQA; X-ray; 1.53 A; A/B/C/D=2-375.
DR   PDB; 7K35; X-ray; 1.20 A; A/B/C/D=2-375.
DR   PDB; 7UA6; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UC9; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UCA; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UCU; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UDD; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UDE; X-ray; 1.10 A; A/B=2-375.
DR   PDB; 7UDR; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UEC; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UEE; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UEF; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UEI; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UEJ; X-ray; 1.20 A; A/B=2-375.
DR   PDB; 7UHV; X-ray; 1.30 A; A/B=2-375.
DR   PDB; 7UHW; X-ray; 1.30 A; A/B=2-375.
DR   PDB; 7UHX; X-ray; 1.30 A; A/B=2-375.
DR   PDB; 8ADH; X-ray; 2.40 A; A=2-375.
DR   PDBsum; 1A71; -.
DR   PDBsum; 1A72; -.
DR   PDBsum; 1ADB; -.
DR   PDBsum; 1ADC; -.
DR   PDBsum; 1ADF; -.
DR   PDBsum; 1ADG; -.
DR   PDBsum; 1AXE; -.
DR   PDBsum; 1AXG; -.
DR   PDBsum; 1BTO; -.
DR   PDBsum; 1HET; -.
DR   PDBsum; 1HEU; -.
DR   PDBsum; 1HF3; -.
DR   PDBsum; 1HLD; -.
DR   PDBsum; 1JU9; -.
DR   PDBsum; 1LDE; -.
DR   PDBsum; 1LDY; -.
DR   PDBsum; 1MG0; -.
DR   PDBsum; 1MGO; -.
DR   PDBsum; 1N8K; -.
DR   PDBsum; 1N92; -.
DR   PDBsum; 1P1R; -.
DR   PDBsum; 1QLH; -.
DR   PDBsum; 1QLJ; -.
DR   PDBsum; 1QV6; -.
DR   PDBsum; 1QV7; -.
DR   PDBsum; 1YE3; -.
DR   PDBsum; 2JHF; -.
DR   PDBsum; 2JHG; -.
DR   PDBsum; 2OHX; -.
DR   PDBsum; 2OXI; -.
DR   PDBsum; 3BTO; -.
DR   PDBsum; 3OQ6; -.
DR   PDBsum; 4DWV; -.
DR   PDBsum; 4DXH; -.
DR   PDBsum; 4NFH; -.
DR   PDBsum; 4NFS; -.
DR   PDBsum; 4NG5; -.
DR   PDBsum; 4XD2; -.
DR   PDBsum; 5ADH; -.
DR   PDBsum; 5CDG; -.
DR   PDBsum; 5CDS; -.
DR   PDBsum; 5CDT; -.
DR   PDBsum; 5CDU; -.
DR   PDBsum; 5KCP; -.
DR   PDBsum; 5KCZ; -.
DR   PDBsum; 5KJ1; -.
DR   PDBsum; 5KJ6; -.
DR   PDBsum; 5KJC; -.
DR   PDBsum; 5KJE; -.
DR   PDBsum; 5KJF; -.
DR   PDBsum; 5VJ5; -.
DR   PDBsum; 5VJG; -.
DR   PDBsum; 5VKR; -.
DR   PDBsum; 5VL0; -.
DR   PDBsum; 5VN1; -.
DR   PDBsum; 6ADH; -.
DR   PDBsum; 6CXX; -.
DR   PDBsum; 6CY3; -.
DR   PDBsum; 6NBB; -.
DR   PDBsum; 6O91; -.
DR   PDBsum; 6OA7; -.
DR   PDBsum; 6OWM; -.
DR   PDBsum; 6OWP; -.
DR   PDBsum; 6XT2; -.
DR   PDBsum; 7ADH; -.
DR   PDBsum; 7JQA; -.
DR   PDBsum; 7K35; -.
DR   PDBsum; 7UA6; -.
DR   PDBsum; 7UC9; -.
DR   PDBsum; 7UCA; -.
DR   PDBsum; 7UCU; -.
DR   PDBsum; 7UDD; -.
DR   PDBsum; 7UDE; -.
DR   PDBsum; 7UDR; -.
DR   PDBsum; 7UEC; -.
DR   PDBsum; 7UEE; -.
DR   PDBsum; 7UEF; -.
DR   PDBsum; 7UEI; -.
DR   PDBsum; 7UEJ; -.
DR   PDBsum; 7UHV; -.
DR   PDBsum; 7UHW; -.
DR   PDBsum; 7UHX; -.
DR   PDBsum; 8ADH; -.
DR   AlphaFoldDB; P00327; -.
DR   SMR; P00327; -.
DR   STRING; 9796.ENSECAP00000033917; -.
DR   BindingDB; P00327; -.
DR   ChEMBL; CHEMBL2111372; -.
DR   DrugCentral; P00327; -.
DR   iPTMnet; P00327; -.
DR   PaxDb; P00327; -.
DR   PeptideAtlas; P00327; -.
DR   GeneID; 100034242; -.
DR   KEGG; ecb:100034242; -.
DR   OrthoDB; 664798at2759; -.
DR   BRENDA; 1.1.1.1; 2120.
DR   SABIO-RK; P00327; -.
DR   EvolutionaryTrace; P00327; -.
DR   PRO; PR:P00327; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IBA:GO_Central.
DR   GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR   GO; GO:0006069; P:ethanol oxidation; IBA:GO_Central.
DR   GO; GO:0042573; P:retinoic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0042572; P:retinol metabolic process; IBA:GO_Central.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Direct protein sequencing;
KW   Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:5466062"
FT   CHAIN           2..375
FT                   /note="Alcohol dehydrogenase E chain"
FT                   /id="PRO_0000160656"
FT   BINDING         47
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:3BTO,
FT                   ECO:0007744|PDB:3OQ6, ECO:0007744|PDB:4DWV,
FT                   ECO:0007744|PDB:4DXH, ECO:0007744|PDB:4NFH,
FT                   ECO:0007744|PDB:4NFS, ECO:0007744|PDB:4NG5,
FT                   ECO:0007744|PDB:4XD2, ECO:0007744|PDB:5ADH,
FT                   ECO:0007744|PDB:6ADH, ECO:0007744|PDB:7ADH,
FT                   ECO:0007744|PDB:8ADH"
FT   BINDING         49
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:P06525"
FT   BINDING         49
FT                   /ligand="substrate"
FT                   /evidence="ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADC,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1QV7, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5"
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P06525"
FT   BINDING         68
FT                   /ligand="substrate"
FT                   /evidence="ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADC,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1MG0, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:3OQ6, ECO:0007744|PDB:4DWV,
FT                   ECO:0007744|PDB:4DXH, ECO:0007744|PDB:4NFH,
FT                   ECO:0007744|PDB:4NFS, ECO:0007744|PDB:4NG5"
FT   BINDING         68
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:3BTO,
FT                   ECO:0007744|PDB:3OQ6, ECO:0007744|PDB:4DWV,
FT                   ECO:0007744|PDB:4DXH, ECO:0007744|PDB:4NFH,
FT                   ECO:0007744|PDB:4NFS, ECO:0007744|PDB:4NG5,
FT                   ECO:0007744|PDB:4XD2, ECO:0007744|PDB:5ADH,
FT                   ECO:0007744|PDB:6ADH, ECO:0007744|PDB:7ADH,
FT                   ECO:0007744|PDB:8ADH"
FT   BINDING         98
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH,
FT                   ECO:0007744|PDB:7ADH, ECO:0007744|PDB:8ADH"
FT   BINDING         101
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH,
FT                   ECO:0007744|PDB:7ADH, ECO:0007744|PDB:8ADH"
FT   BINDING         104
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH,
FT                   ECO:0007744|PDB:7ADH, ECO:0007744|PDB:8ADH"
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0000269|PubMed:178875, ECO:0007744|PDB:1A71,
FT                   ECO:0007744|PDB:1A72, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1ADC, ECO:0007744|PDB:1ADF,
FT                   ECO:0007744|PDB:1ADG, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1AXG, ECO:0007744|PDB:1BTO,
FT                   ECO:0007744|PDB:1HET, ECO:0007744|PDB:1HLD,
FT                   ECO:0007744|PDB:1JU9, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QLJ,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:1YE3, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH,
FT                   ECO:0007744|PDB:7ADH, ECO:0007744|PDB:8ADH"
FT   BINDING         175
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1A71, ECO:0007744|PDB:1A72,
FT                   ECO:0007744|PDB:1ADB, ECO:0007744|PDB:1ADC,
FT                   ECO:0007744|PDB:1ADF, ECO:0007744|PDB:1ADG,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1JU9,
FT                   ECO:0007744|PDB:1LDE, ECO:0007744|PDB:1LDY,
FT                   ECO:0007744|PDB:1MG0, ECO:0007744|PDB:1MGO,
FT                   ECO:0007744|PDB:1N8K, ECO:0007744|PDB:1N92,
FT                   ECO:0007744|PDB:1P1R, ECO:0007744|PDB:1QLH,
FT                   ECO:0007744|PDB:1QLJ, ECO:0007744|PDB:1QV6,
FT                   ECO:0007744|PDB:1QV7, ECO:0007744|PDB:1YE3,
FT                   ECO:0007744|PDB:2JHG, ECO:0007744|PDB:2OHX,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH,
FT                   ECO:0007744|PDB:7ADH, ECO:0007744|PDB:8ADH"
FT   BINDING         200..205
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1ADB, ECO:0007744|PDB:1AXE,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HEU, ECO:0007744|PDB:1HF3,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1JU9,
FT                   ECO:0007744|PDB:1LDE, ECO:0007744|PDB:1LDY,
FT                   ECO:0007744|PDB:1MG0, ECO:0007744|PDB:1MGO,
FT                   ECO:0007744|PDB:1N8K, ECO:0007744|PDB:1N92,
FT                   ECO:0007744|PDB:1P1R, ECO:0007744|PDB:1QV6,
FT                   ECO:0007744|PDB:1QV7, ECO:0007744|PDB:2JHF,
FT                   ECO:0007744|PDB:2JHG, ECO:0007744|PDB:2OHX,
FT                   ECO:0007744|PDB:2OXI, ECO:0007744|PDB:3BTO,
FT                   ECO:0007744|PDB:3OQ6, ECO:0007744|PDB:4DWV,
FT                   ECO:0007744|PDB:4DXH, ECO:0007744|PDB:4NFH,
FT                   ECO:0007744|PDB:4XD2, ECO:0007744|PDB:6ADH"
FT   BINDING         224
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HEU, ECO:0007744|PDB:1HF3,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1JU9,
FT                   ECO:0007744|PDB:1LDE, ECO:0007744|PDB:1LDY,
FT                   ECO:0007744|PDB:1MG0, ECO:0007744|PDB:1MGO,
FT                   ECO:0007744|PDB:1N8K, ECO:0007744|PDB:1N92,
FT                   ECO:0007744|PDB:1P1R, ECO:0007744|PDB:1QLH,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:2JHF, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH"
FT   BINDING         229
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HEU, ECO:0007744|PDB:1HF3,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1JU9,
FT                   ECO:0007744|PDB:1LDE, ECO:0007744|PDB:1MGO,
FT                   ECO:0007744|PDB:1N8K, ECO:0007744|PDB:1N92,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:2JHF,
FT                   ECO:0007744|PDB:2JHG, ECO:0007744|PDB:2OHX,
FT                   ECO:0007744|PDB:2OXI, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:5ADH, ECO:0007744|PDB:6ADH"
FT   BINDING         293..295
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HEU, ECO:0007744|PDB:1HF3,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QLH, ECO:0007744|PDB:1QV6,
FT                   ECO:0007744|PDB:1QV7, ECO:0007744|PDB:2JHF,
FT                   ECO:0007744|PDB:2JHG, ECO:0007744|PDB:2OHX,
FT                   ECO:0007744|PDB:2OXI, ECO:0007744|PDB:3BTO,
FT                   ECO:0007744|PDB:3OQ6, ECO:0007744|PDB:4DWV,
FT                   ECO:0007744|PDB:4DXH, ECO:0007744|PDB:4NFH,
FT                   ECO:0007744|PDB:4NFS, ECO:0007744|PDB:4NG5,
FT                   ECO:0007744|PDB:4XD2, ECO:0007744|PDB:6ADH"
FT   BINDING         293
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:P06525"
FT   BINDING         320
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:P06525"
FT   BINDING         370
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000269|PubMed:15299346,
FT                   ECO:0007744|PDB:1A71, ECO:0007744|PDB:1ADB,
FT                   ECO:0007744|PDB:1AXE, ECO:0007744|PDB:1AXG,
FT                   ECO:0007744|PDB:1BTO, ECO:0007744|PDB:1HET,
FT                   ECO:0007744|PDB:1HEU, ECO:0007744|PDB:1HF3,
FT                   ECO:0007744|PDB:1HLD, ECO:0007744|PDB:1LDE,
FT                   ECO:0007744|PDB:1LDY, ECO:0007744|PDB:1MG0,
FT                   ECO:0007744|PDB:1MGO, ECO:0007744|PDB:1N8K,
FT                   ECO:0007744|PDB:1N92, ECO:0007744|PDB:1P1R,
FT                   ECO:0007744|PDB:1QV6, ECO:0007744|PDB:1QV7,
FT                   ECO:0007744|PDB:2JHF, ECO:0007744|PDB:2JHG,
FT                   ECO:0007744|PDB:2OHX, ECO:0007744|PDB:2OXI,
FT                   ECO:0007744|PDB:3BTO, ECO:0007744|PDB:3OQ6,
FT                   ECO:0007744|PDB:4DWV, ECO:0007744|PDB:4DXH,
FT                   ECO:0007744|PDB:4NFH, ECO:0007744|PDB:4NFS,
FT                   ECO:0007744|PDB:4NG5, ECO:0007744|PDB:4XD2,
FT                   ECO:0007744|PDB:6ADH"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:5466062"
FT   HELIX           3..5
FT                   /evidence="ECO:0007829|PDB:1ADG"
FT   STRAND          8..15
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          17..20
FT                   /evidence="ECO:0007829|PDB:6NBB"
FT   STRAND          23..29
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          36..45
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           48..54
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          56..58
FT                   /evidence="ECO:0007829|PDB:1MGO"
FT   STRAND          62..64
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          69..77
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          89..92
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          99..101
FT                   /evidence="ECO:0007829|PDB:4NFS"
FT   HELIX           102..105
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          106..108
FT                   /evidence="ECO:0007829|PDB:4NFS"
FT   STRAND          116..119
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          125..127
FT                   /evidence="ECO:0007829|PDB:6ADH"
FT   STRAND          130..133
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          136..139
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   TURN            142..144
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          147..154
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           155..157
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          158..160
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           167..170
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           171..174
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           176..185
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   TURN            186..188
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          195..199
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           203..214
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          218..223
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           227..229
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           230..235
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          239..242
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           244..246
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           251..258
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          263..268
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           273..282
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   TURN            285..287
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          289..292
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          297..299
FT                   /evidence="ECO:0007829|PDB:6ADH"
FT   STRAND          302..304
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           307..310
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          314..317
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           320..322
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           325..337
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          338..341
FT                   /evidence="ECO:0007829|PDB:7ADH"
FT   HELIX           344..346
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          347..352
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           353..355
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   HELIX           356..364
FT                   /evidence="ECO:0007829|PDB:2JHF"
FT   STRAND          365..367
FT                   /evidence="ECO:0007829|PDB:6ADH"
FT   STRAND          369..374
FT                   /evidence="ECO:0007829|PDB:2JHF"
SQ   SEQUENCE   375 AA;  39936 MW;  DA701D2F6AB69C9D CRC64;
     MSTAGKVIKC KAAVLWEEKK PFSIEEVEVA PPKAHEVRIK MVATGICRSD DHVVSGTLVT
     PLPVIAGHEA AGIVESIGEG VTTVRPGDKV IPLFTPQCGK CRVCKHPEGN FCLKNDLSMP
     RGTMQDGTSR FTCRGKPIHH FLGTSTFSQY TVVDEISVAK IDAASPLEKV CLIGCGFSTG
     YGSAVKVAKV TQGSTCAVFG LGGVGLSVIM GCKAAGAARI IGVDINKDKF AKAKEVGATE
     CVNPQDYKKP IQEVLTEMSN GGVDFSFEVI GRLDTMVTAL SCCQEAYGVS VIVGVPPDSQ
     NLSMNPMLLL SGRTWKGAIF GGFKSKDSVP KLVADFMAKK FALDPLITHV LPFEKINEGF
     DLLRSGESIR TILTF
 
 
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