ID   DSS1_CAEEL              Reviewed;          82 AA.
AC   Q95Y72;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable 26S proteasome complex subunit dss-1;
DE   AltName: Full=Deleted in split hand/split foot protein 1 homolog;
GN   Name=dss-1; ORFNames=Y119D3B.15;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=18471277; DOI=10.1186/1471-213x-8-51;
RA   Pispa J., Palmen S., Holmberg C.I., Jantti J.;
RT   "C. elegans dss-1 is functionally conserved and required for oogenesis and
RT   larval growth.";
RL   BMC Dev. Biol. 8:51-51(2008).
CC   -!- FUNCTION: Subunit of the 26S proteasome which plays a role in
CC       ubiquitin-dependent proteolysis. Has an essential role in oogenesis and
CC       larval growth. Required for intestinal function and default lifespan.
CC       {ECO:0000269|PubMed:18471277}.
CC   -!- SUBUNIT: Part of the 26S proteasome. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q95Y72; Q04908: rpn-3; NbExp=2; IntAct=EBI-312245, EBI-312239;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18471277}. Cytoplasm
CC       {ECO:0000269|PubMed:18471277}. Note=Diffuse in cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed in intestinal epithelium and head
CC       neurons. {ECO:0000269|PubMed:18471277}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in larval and adult stages.
CC       {ECO:0000269|PubMed:18471277}.
CC   -!- DISRUPTION PHENOTYPE: Embryonic lethality, growth defects, larval
CC       arrest, reduced lifespan, and sterility. {ECO:0000269|PubMed:18471277}.
CC   -!- SIMILARITY: Belongs to the DSS1/SEM1 family. {ECO:0000305}.
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DR   EMBL; FO081827; CCD73924.1; -; Genomic_DNA.
DR   RefSeq; NP_497346.2; NM_064945.4.
DR   AlphaFoldDB; Q95Y72; -.
DR   BioGRID; 40544; 1.
DR   DIP; DIP-24478N; -.
DR   IntAct; Q95Y72; 1.
DR   STRING; 6239.Y119D3B.15; -.
DR   EPD; Q95Y72; -.
DR   PaxDb; Q95Y72; -.
DR   PeptideAtlas; Q95Y72; -.
DR   EnsemblMetazoa; Y119D3B.15.1; Y119D3B.15.1; WBGene00022492.
DR   EnsemblMetazoa; Y119D3B.15.2; Y119D3B.15.2; WBGene00022492.
DR   WormBase; Y119D3B.15; CE34396; WBGene00022492; dss-1.
DR   eggNOG; KOG4764; Eukaryota.
DR   HOGENOM; CLU_141774_1_2_1; -.
DR   InParanoid; Q95Y72; -.
DR   OMA; NEVNVWE; -.
DR   PRO; PR:Q95Y72; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022492; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; ISS:WormBase.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0060429; P:epithelium development; IMP:WormBase.
DR   GO; GO:0050892; P:intestinal absorption; IMP:WormBase.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0048477; P:oogenesis; IMP:WormBase.
DR   GO; GO:0045927; P:positive regulation of growth; IGI:WormBase.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IGI:WormBase.
DR   GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR   GO; GO:0040025; P:vulval development; IMP:WormBase.
DR   InterPro; IPR007834; DSS1_SEM1.
DR   PANTHER; PTHR16771; PTHR16771; 1.
DR   Pfam; PF05160; DSS1_SEM1; 1.
DR   SMART; SM01385; DSS1_SEM1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Nucleus; Proteasome; Reference proteome.
FT   CHAIN           1..82
FT                   /note="Probable 26S proteasome complex subunit dss-1"
FT                   /id="PRO_0000122963"
FT   REGION          56..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   82 AA;  9502 MW;  C24EB9496A089389 CRC64;
     MSSTAAKKDV KSSAVPVTAV VEKKEFEEEE FEEFPVQEWA ERAEGEEDDV NVWEDNWDDE
     THESEFSKQL KEELRKSGHQ VA