DT3UO_HUMAN
ID DT3UO_HUMAN Reviewed; 34 AA.
AC P0DPQ6;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 1.
DT 03-AUG-2022, entry version 20.
DE RecName: Full=DDIT3 upstream open reading frame protein {ECO:0000305};
DE AltName: Full=Alternative DDIT3 protein {ECO:0000303|PubMed:29083303, ECO:0000305};
DE Short=AltDDIT3 {ECO:0000303|PubMed:29083303};
GN Name=DDIT3 {ECO:0000312|HGNC:HGNC:2726};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP SUBCELLULAR LOCATION, ALTERNATIVE INITIATION (ISOFORM ALTDDIT3), AND
RP SUBUNIT.
RX PubMed=29083303; DOI=10.7554/elife.27860;
RA Samandi S., Roy A.V., Delcourt V., Lucier J.F., Gagnon J., Beaudoin M.C.,
RA Vanderperre B., Breton M.A., Motard J., Jacques J.F., Brunelle M.,
RA Gagnon-Arsenault I., Fournier I., Ouangraoua A., Hunting D.J., Cohen A.A.,
RA Landry C.R., Scott M.S., Roucou X.;
RT "Deep transcriptome annotation enables the discovery and functional
RT characterization of cryptic small proteins.";
RL Elife 6:0-0(2017).
CC -!- FUNCTION: [Isoform AltDDIT3]: Product of the upstream open reading
CC frame (uORF) of DDIT3/CHOP that is specifically produced in absence of
CC stress, thereby preventing translation of downstream stress effector
CC DDIT3/CHOP. {ECO:0000250|UniProtKB:A0A2R8VHR8}.
CC -!- SUBUNIT: [Isoform AltDDIT3]: Interacts with DDIT3 (isoform 1).
CC {ECO:0000269|PubMed:29083303}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29083303}. Cytoplasm
CC {ECO:0000269|PubMed:29083303}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing, Alternative initiation; Named isoforms=3;
CC Name=AltDDIT3 {ECO:0000303|PubMed:29083303};
CC IsoId=P0DPQ6-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P35638-1; Sequence=External;
CC Name=2;
CC IsoId=P35638-2; Sequence=External;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC022506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0DPQ6; -.
DR PRIDE; P0DPQ6; -.
DR Antibodypedia; 81996; 1 antibodies from 1 providers.
DR GeneCards; DDIT3; -.
DR HGNC; HGNC:2726; DDIT3.
DR HPA; ENSG00000285133; Tissue enhanced (brain, skeletal muscle).
DR MalaCards; DDIT3; -.
DR neXtProt; NX_P0DPQ6; -.
DR VEuPathDB; HostDB:ENSG00000285133; -.
DR GeneTree; ENSGT01010000223049; -.
DR PathwayCommons; P0DPQ6; -.
DR ChiTaRS; DDIT3; human.
DR Pharos; P0DPQ6; Tbio.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Alternative initiation; Alternative splicing; Cytoplasm; Nucleus;
KW Reference proteome.
FT CHAIN 1..34
FT /note="DDIT3 upstream open reading frame protein"
FT /id="PRO_0000445431"
SQ SEQUENCE 34 AA; 4284 MW; 7F6224E3D6DA1B02 CRC64;
MLKMSGWQRQ SQNQSWNLRR ECSRRKCIFI HHHT
