DT3UO_MOUSE
ID DT3UO_MOUSE Reviewed; 34 AA.
AC A0A2R8VHR8;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2018, sequence version 1.
DT 03-AUG-2022, entry version 15.
DE RecName: Full=DDIT3 upstream open reading frame protein {ECO:0000305};
DE AltName: Full=Alternative DDIT3 proteins {ECO:0000250|UniProtKB:P0DPQ6};
DE Short=AltDDIT3 {ECO:0000250|UniProtKB:P0DPQ6};
GN Name=Ddit3 {ECO:0000312|MGI:MGI:109247};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=21285359; DOI=10.1074/jbc.m110.216093;
RA Palam L.R., Baird T.D., Wek R.C.;
RT "Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory
RT upstream ORF to enhance CHOP translation.";
RL J. Biol. Chem. 286:10939-10949(2011).
CC -!- FUNCTION: [Isoform AltDDIT3]: Product of the upstream open reading
CC frame (uORF) of DDIT3/CHOP that is specifically produced in absence of
CC stress, thereby preventing translation of downstream stress effector
CC DDIT3/CHOP. {ECO:0000269|PubMed:21285359}.
CC -!- SUBUNIT: Interacts with DDIT3 (isoform 1).
CC {ECO:0000250|UniProtKB:P0DPQ6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H6Z9}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9H6Z9}. Note=Colocalizes with WDR83 in the
CC cytoplasm. {ECO:0000250|UniProtKB:Q62630}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=AltDDIT3;
CC IsoId=A0A2R8VHR8-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P35639-1; Sequence=External;
CC -!- INDUCTION: [Isoform AltDDIT3]: Produced in absence of stress: this uORF
CC is translated, thereby preventing translation of downstream ORF, the
CC stress effector DDIT3/CHOP (PubMed:21285359). This uORF is not
CC translated in response to stress (PubMed:21285359).
CC {ECO:0000269|PubMed:21285359}.
CC -!- MISCELLANEOUS: [Isoform AltDDIT3]: Product of the upstream open reading
CC frame of this bicistronic gene. {ECO:0000250|UniProtKB:P0DPQ6}.
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DR EMBL; AC144852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8VHR8; -.
DR Ensembl; ENSMUST00000230446; ENSMUSP00000155363; ENSMUSG00000116429. [A0A2R8VHR8-1]
DR MGI; MGI:109247; Ddit3.
DR VEuPathDB; HostDB:ENSMUSG00000116429; -.
DR GeneTree; ENSGT01010000223049; -.
DR ChiTaRS; Ddit3; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000116429; Expressed in embryonic brain and 30 other tissues.
DR GO; GO:1990622; C:CHOP-ATF3 complex; ISO:MGI.
DR GO; GO:1990617; C:CHOP-ATF4 complex; ISO:MGI.
DR GO; GO:0036488; C:CHOP-C/EBP complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005770; C:late endosome; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0008140; F:cAMP response element binding protein binding; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0043522; F:leucine zipper domain binding; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:MGI.
DR GO; GO:0060840; P:artery development; IMP:MGI.
DR GO; GO:0045454; P:cell redox homeostasis; ISO:MGI.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:MGI.
DR GO; GO:0006983; P:ER overload response; IMP:MGI.
DR GO; GO:0010467; P:gene expression; IGI:MGI.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:MGI.
DR GO; GO:0032792; P:negative regulation of CREB transcription factor activity; ISO:MGI.
DR GO; GO:2000016; P:negative regulation of determination of dorsal identity; ISO:MGI.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IGI:MGI.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:MGI.
DR GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:MGI.
DR GO; GO:0032713; P:negative regulation of interleukin-4 production; ISO:MGI.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR GO; GO:0051898; P:negative regulation of protein kinase B signaling; ISO:MGI.
DR GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0034263; P:positive regulation of autophagy in response to ER overload; ISO:MGI.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
DR GO; GO:0010506; P:regulation of autophagy; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:MGI.
DR GO; GO:0036119; P:response to platelet-derived growth factor; IMP:MGI.
DR GO; GO:0006986; P:response to unfolded protein; ISO:MGI.
DR GO; GO:0009611; P:response to wounding; IMP:MGI.
DR GO; GO:0007605; P:sensory perception of sound; IGI:MGI.
DR GO; GO:1904738; P:vascular associated smooth muscle cell migration; IMP:MGI.
DR GO; GO:1990874; P:vascular associated smooth muscle cell proliferation; IMP:MGI.
PE 2: Evidence at transcript level;
KW Alternative initiation; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..34
FT /note="DDIT3 upstream open reading frame protein"
FT /id="PRO_0000450345"
SQ SEQUENCE 34 AA; 4240 MW; 7F62225570B6CB02 CRC64;
MLKMSGWQRQ SQNNSRNLRR ECSRRKCIFI HHHT
