ID   DTB1A_DANRE             Reviewed;         362 AA.
AC   Q7ZWE6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Dysbindin-A;
DE   AltName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 8-A;
DE            Short=BLOC-1 subunit 8-A;
DE   AltName: Full=Dystrobrevin-binding protein 1-A;
GN   Name=dtnbp1a; Synonyms=bloc1s8, dtnbp1; ORFNames=zgc:56462;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC       for normal biogenesis of lysosome-related organelles (LRO), such as
CC       platelet dense granules and melanosomes. Plays a role in intracellular
CC       vesicle trafficking. Plays a role in synaptic vesicle trafficking and
CC       in neurotransmitter release. May be required for normal dopamine
CC       homeostasis in the cerebral cortex, hippocampus, and hypothalamus.
CC       Plays a role in the regulation of cell surface exposure of DRD2.
CC       Contributes to the regulation of dopamine signaling. May play a role in
CC       actin cytoskeleton reorganization and neurite outgrowth (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex 1 (BLOC-1). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Melanosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Postsynaptic density {ECO:0000250}. Endoplasmic
CC       reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dysbindin family. {ECO:0000305}.
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DR   EMBL; BC049451; AAH49451.1; -; mRNA.
DR   RefSeq; NP_957428.1; NM_201134.1.
DR   AlphaFoldDB; Q7ZWE6; -.
DR   SMR; Q7ZWE6; -.
DR   STRING; 7955.ENSDARP00000071887; -.
DR   PaxDb; Q7ZWE6; -.
DR   GeneID; 394109; -.
DR   KEGG; dre:394109; -.
DR   CTD; 394109; -.
DR   ZFIN; ZDB-GENE-040426-1036; dtnbp1a.
DR   eggNOG; ENOG502QRS9; Eukaryota.
DR   InParanoid; Q7ZWE6; -.
DR   OrthoDB; 862376at2759; -.
DR   PhylomeDB; Q7ZWE6; -.
DR   PRO; PR:Q7ZWE6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR   GO; GO:0060155; P:platelet dense granule organization; IBA:GO_Central.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IBA:GO_Central.
DR   InterPro; IPR007531; Dysbindin.
DR   PANTHER; PTHR16294; PTHR16294; 1.
DR   Pfam; PF04440; Dysbindin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum;
KW   Endosome; Membrane; Nucleus; Reference proteome; Synapse.
FT   CHAIN           1..362
FT                   /note="Dysbindin-A"
FT                   /id="PRO_0000267212"
FT   REGION          263..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          109..180
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        278..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   362 AA;  40857 MW;  5E391572E4C08688 CRC64;
     MFENFREKLQ TVQQDFTSGI KTLSDKSKEA KVKKKQRRDE YLPQYSAGVE LLSRYEDTWV
     ALHKRAKESA KSGETVDGEV VMLCAHWEKR RGAVLELQEQ LQQIPTFLSD LETITSRIAH
     LEADFEEMES RLVYLEDLCA QCEHQRFKQF QILQLENYKK KKRKELESCK AELDAEHAQK
     VLEMEHAQQV KLKERRKYFE EAFQQDMEQY LSTGYLQITD RRDPLGSMSS MEVNVDLLEQ
     MDLTDVSDHE ALDVFLSSVG EESSAVSPDA GGPSLEPGSS PSDISLKVPS QSELRHNISS
     ISSSCTDTVS GTTEGPDEEE SSSGDSPLVQ SDEEEVHADT ALMGLPETEA LKSSDDSDTQ
     AP