ADH1_DROMO
ID ADH1_DROMO Reviewed; 254 AA.
AC P09370; Q6UPV9; Q6UPW6; Q6UPX2; Q867T9;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Alcohol dehydrogenase 1;
DE EC=1.1.1.1;
GN Name=Adh1; ORFNames=GI17644;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND
RP LEU-236.
RC STRAIN=VRF;
RX PubMed=3224808; DOI=10.1093/genetics/120.3.713;
RA Atkinson P.W., Mills L.E., Starmer W.T., Sullivan D.T.;
RT "Structure and evolution of the Adh genes of Drosophila mojavensis.";
RL Genetics 120:713-723(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-187; VAL-189 AND
RP LEU-236.
RC STRAIN=VRF;
RX PubMed=1317314; DOI=10.1093/genetics/131.1.143;
RA Bayer C.A., Curtiss S.W., Weaver J.A., Sullivan D.T.;
RT "Delineation of cis-acting sequences required for expression of Drosophila
RT mojavensis Adh-1.";
RL Genetics 131:143-153(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MJBC 103.3, MJBC 108.5, MJBC 115.4, MJBC 157.3, MJBC 202.2,
RC MJBC 205.1, MJBC 25.3, MJBC 33.3, MJBC 35.1, MJBC 39.3, MJBC 47.3, MJBC 80,
RC and MJBC 95.1;
RX PubMed=12586706; DOI=10.1093/genetics/163.1.181;
RA Matzkin L.M., Eanes W.F.;
RT "Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic
RT Drosophila.";
RL Genetics 163:181-194(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=MJS 115, MJS 122, MJS 127, MJS 132, MJS 14, MJS 154, MJS 36,
RC MJS 58.2, MJS 68, MJS 84, and MJS 87;
RX PubMed=14660699; DOI=10.1093/molbev/msh019;
RA Matzkin L.M.;
RT "Population genetics and geographic variation of alcohol dehydrogenase
RT (Adh) paralogs and glucose-6-phosphate dehydrogenase (G6pd) in Drosophila
RT mojavensis.";
RL Mol. Biol. Evol. 21:276-285(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10001};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10001};
CC -!- SUBUNIT: Homodimer.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; M37276; AAA28335.1; -; Genomic_DNA.
DR EMBL; X12536; CAA31055.1; -; Genomic_DNA.
DR EMBL; AY154827; AAN86863.1; -; Genomic_DNA.
DR EMBL; AY154828; AAN86864.1; -; Genomic_DNA.
DR EMBL; AY154829; AAN86865.1; -; Genomic_DNA.
DR EMBL; AY154830; AAN86866.1; -; Genomic_DNA.
DR EMBL; AY154831; AAN86867.1; -; Genomic_DNA.
DR EMBL; AY154832; AAN86868.1; -; Genomic_DNA.
DR EMBL; AY154833; AAN86869.1; -; Genomic_DNA.
DR EMBL; AY154834; AAN86870.1; -; Genomic_DNA.
DR EMBL; AY154835; AAN86871.1; -; Genomic_DNA.
DR EMBL; AY154836; AAN86872.1; -; Genomic_DNA.
DR EMBL; AY154837; AAN86873.1; -; Genomic_DNA.
DR EMBL; AY154838; AAN86874.1; -; Genomic_DNA.
DR EMBL; AY154839; AAN86875.1; -; Genomic_DNA.
DR EMBL; AY364493; AAR12927.1; -; Genomic_DNA.
DR EMBL; AY364494; AAR12928.1; -; Genomic_DNA.
DR EMBL; AY364495; AAR12929.1; -; Genomic_DNA.
DR EMBL; AY364496; AAR12930.1; -; Genomic_DNA.
DR EMBL; AY364497; AAR12931.1; -; Genomic_DNA.
DR EMBL; AY364498; AAR12932.1; -; Genomic_DNA.
DR EMBL; AY364499; AAR12933.1; -; Genomic_DNA.
DR EMBL; AY364500; AAR12934.1; -; Genomic_DNA.
DR EMBL; AY364501; AAR12935.1; -; Genomic_DNA.
DR EMBL; AY364502; AAR12936.1; -; Genomic_DNA.
DR EMBL; AY364503; AAR12937.1; -; Genomic_DNA.
DR EMBL; AY364504; AAR12938.1; -; Genomic_DNA.
DR EMBL; AY364505; AAR12939.1; -; Genomic_DNA.
DR EMBL; AY364506; AAR12940.1; -; Genomic_DNA.
DR EMBL; AY364507; AAR12941.1; -; Genomic_DNA.
DR EMBL; CH933807; EDW12372.1; -; Genomic_DNA.
DR PIR; S01902; S01902.
DR RefSeq; XP_002002930.1; XM_002002894.2.
DR AlphaFoldDB; P09370; -.
DR SMR; P09370; -.
DR STRING; 7230.FBpp0166861; -.
DR EnsemblMetazoa; FBtr0168369; FBpp0166861; FBgn0012566.
DR GeneID; 6576953; -.
DR KEGG; dmo:Dmoj_GI17644; -.
DR eggNOG; KOG4169; Eukaryota.
DR HOGENOM; CLU_010194_2_16_1; -.
DR InParanoid; P09370; -.
DR OMA; NAGICND; -.
DR OrthoDB; 1053465at2759; -.
DR PhylomeDB; P09370; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR InterPro; IPR002425; ADH_Drosophila-type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR01168; ALCDHDRGNASE.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW NAD; Oxidoreductase; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..254
FT /note="Alcohol dehydrogenase 1"
FT /id="PRO_0000054478"
FT ACT_SITE 151
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 10..33
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 138
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VARIANT 187
FT /note="P -> T (in strain: VRF)"
FT /evidence="ECO:0000269|PubMed:1317314,
FT ECO:0000269|PubMed:3224808"
FT VARIANT 189
FT /note="L -> V (in strain: VRF)"
FT /evidence="ECO:0000269|PubMed:1317314,
FT ECO:0000269|PubMed:3224808"
FT VARIANT 236
FT /note="V -> L (in strain: VRF)"
FT /evidence="ECO:0000269|PubMed:1317314,
FT ECO:0000269|PubMed:3224808"
SQ SEQUENCE 254 AA; 27561 MW; 4ECDEF98EB9A99ED CRC64;
MAIANKNIIF VAGLGGIGFD TSREIVKKGP KNLVILDRIE NPAAIAELKA LNPKVTVTFY
LYDVTVSVAE STKLLQKIFD QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTITAIMS
FWDKRKGGPG GVIANVCSVT GFNAIYQVPV YSASKAAALS FTNSLAKLAP ITGVTAYSIN
PGITKTPLLH KFNSWLDVEP RVGELLLEHP TQTSLECAQN FVKAIEANQN GAIWKVDLGT
LEAIEWTKHW DSHI
