DTH1_GIRTI
ID DTH1_GIRTI Reviewed; 533 AA.
AC Q00400;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Homeobox protein DTH-1;
GN Name=DTH-1;
OS Girardia tigrina (Planarian) (Dugesia tigrina).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC Dugesiidae; Girardia.
OX NCBI_TaxID=6162;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8104142; DOI=10.1242/dev.118.1.241;
RA Garcia-Fernandez J., Baguna J., Salo E.;
RT "Genomic organization and expression of the planarian homeobox genes Dth-1
RT and Dth-2.";
RL Development 118:241-253(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 83-533.
RX PubMed=1714599; DOI=10.1073/pnas.88.16.7338;
RA Salo E., Garcia-Fernandez J., Baguna J.;
RT "Planarian homeobox genes: cloning, sequence analysis, and expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:7338-7342(1991).
CC -!- FUNCTION: This protein might be involved in determination and/or
CC differentiation of nerve cells in the continuous replacement of neurons
CC in the cephalic region.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Intestine and unidentified peripheral parenchymal
CC cells. Slightly higher levels in the cephalic region compared to other
CC body regions.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; X69203; CAA49141.1; -; Genomic_DNA.
DR EMBL; X69200; CAA49141.1; JOINED; Genomic_DNA.
DR EMBL; X69201; CAA49141.1; JOINED; Genomic_DNA.
DR EMBL; X56499; CAA39854.1; -; mRNA.
DR PIR; S33701; S33701.
DR AlphaFoldDB; Q00400; -.
DR SMR; Q00400; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus.
FT CHAIN 1..533
FT /note="Homeobox protein DTH-1"
FT /id="PRO_0000049063"
FT DNA_BIND 377..436
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 60275 MW; 2AC65D21BDEA4CAE CRC64;
MSSNGDSVKY DTNFDREGYS TDSSNECPNQ IDDPLNGIPN SQNSENFQLY SRNNNANELH
ETFPTTIPIA QQVHLSSFRN SGMVNSNSRS IGPDGSIYSI QPFDRALLQR NFIPNDEMTS
NMSFVQMLNS ANYDQIEPAF YQNMPGIGNS FMMQSILNPN PNDQEIDNPI SDNSTYVLVQ
GDSNIPTNPQ SNPINPTYVS LDLNDCRSNM FEYPSQTGHQ YPDINGNGPR LLHCKQELSY
PQTNISPFDY RLSRSMQSNT PLSSYKLSLP EIKTISNDWI KGSQNVNFNQ NQLLRSTNVS
DYTLIKNLPQ NLPNPNQTDS IYSSSINENN QPIRNYDSPN PDREDDSEIH ENPNPHDTSS
VENNDNENSS SGDIGKKRKR RVLFSKKQIL ELERHFRQKK YLSAPEREHL ANLIGLSPTQ
VKIWFQNHRY KMKRAHHEKA LEMGNLAVNR RLNQSMFNDS KSHLPGNFEL GINNSFYNSN
LALGNLSLNP AVNLMGRIPG MSSMLPTYPN GSQSYFNNIN QATLTGSNSS WGV
