ID   DTML3_DICDI             Reviewed;         597 AA.
AC   Q54CP9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Dictomallein-3;
DE            EC=3.4.24.-;
DE   Flags: Precursor;
GN   Name=dtmlC; ORFNames=DDB_G0292824;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dictomallein family. {ECO:0000305}.
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DR   EMBL; AAFI02000197; EAL60961.1; -; Genomic_DNA.
DR   RefSeq; XP_629367.1; XM_629365.1.
DR   AlphaFoldDB; Q54CP9; -.
DR   SMR; Q54CP9; -.
DR   STRING; 44689.DDB0252869; -.
DR   PaxDb; Q54CP9; -.
DR   EnsemblProtists; EAL60961; EAL60961; DDB_G0292824.
DR   GeneID; 8628884; -.
DR   KEGG; ddi:DDB_G0292824; -.
DR   dictyBase; DDB_G0292824; -.
DR   eggNOG; ENOG502SN3T; Eukaryota.
DR   HOGENOM; CLU_451780_0_0_1; -.
DR   InParanoid; Q54CP9; -.
DR   OMA; WWTPTVD; -.
DR   PhylomeDB; Q54CP9; -.
DR   PRO; PR:Q54CP9; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR019503; Peptidase_M66_dom.
DR   PROSITE; PS51694; PEPTIDASE_M66; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW   Secreted; Signal; Zinc.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..597
FT                   /note="Dictomallein-3"
FT                   /id="PRO_0000322648"
FT   DOMAIN          148..409
FT                   /note="Peptidase M66"
FT   ACT_SITE        302
FT                   /evidence="ECO:0000250"
FT   BINDING         301
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         305
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         311
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   597 AA;  67570 MW;  BB0287B68B03480F CRC64;
     MKLILILIFL FSCILFINCE NLIKVLDVRL AQTHVIPVEG KTWNLNNNIQ HMSIVGNRRA
     FLLASFDDPT QTYYTTIWFN DKLVGPLKLN DPSQLPPTED KGEKYSTVHH SIMLSKEWVK
     VGMKIQFFTI GNDGNGSSVV KSSDFFYPDV GQDYTLKMWT LPFYLFGAND TNTQPFSKTK
     GIDSEITKEL IEKWSCSDLQ AINHPIQKID WSYFVMEPRN GNPAMVITNS DQKKDGYAIM
     SGVLNILTQI RKVFGESSSS IQIYSPLLHL DSKGKYADPY GGLGGGSRGT GDYTYKGIFI
     HEQGHAMGLP HAGEAFDKGT FPYQKGSLSG SEWGFDANHN EFLGNFLPPT AEYYRNCQKS
     FLIDNKGRCI KQSVMQGGAG DQSSKYRFSM FADYEMTTIQ NYFKNSIYYD ETNGTYKKWN
     DTSKSYYDYK PITQNKGLWG IDDGTPIERD IDVYTILFTH STVGPKELSQ IYPLLKSKGN
     LMRQFDPTNK TEMAIIIPNT GAIPWYCHDS GCDYTVRVTF DDNSLQHVLL QQGKRKYWKP
     MSDLKDNIMD PKSSDSFMLG GINVKANKKI NKVELLETLL GWNGISNNAT VLASKSF