ID   DTPA_ERWP6              Reviewed;         492 AA.
AC   D2TBH1;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Dipeptide and tripeptide permease A {ECO:0000255|HAMAP-Rule:MF_01878};
GN   Name=dtpA {ECO:0000255|HAMAP-Rule:MF_01878}; OrderedLocusNames=EPYR_02021;
OS   Erwinia pyrifoliae (strain DSM 12163 / CIP 106111 / Ep16/96).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=644651;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12163 / CIP 106111 / Ep16/96;
RX   PubMed=20047678; DOI=10.1186/1471-2164-11-2;
RA   Smits T.H., Jaenicke S., Rezzonico F., Kamber T., Goesmann A., Frey J.E.,
RA   Duffy B.;
RT   "Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae
RT   DSM 12163T and comparative genomic insights into plant pathogenicity.";
RL   BMC Genomics 11:2-2(2010).
CC   -!- FUNCTION: Proton-dependent permease that transports di- and
CC       tripeptides. {ECO:0000255|HAMAP-Rule:MF_01878}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01878}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01878}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01878}.
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DR   EMBL; FN392235; CAY74401.1; -; Genomic_DNA.
DR   RefSeq; WP_012668179.1; NC_017390.1.
DR   AlphaFoldDB; D2TBH1; -.
DR   SMR; D2TBH1; -.
DR   EnsemblBacteria; CAY74401; CAY74401; EPYR_02021.
DR   KEGG; epr:EPYR_02021; -.
DR   PATRIC; fig|644651.3.peg.1856; -.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; QMMGVWF; -.
DR   Proteomes; UP000008690; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01878; PTR2_DtpA_subfam; 1.
DR   InterPro; IPR023517; AA/pep_transptr_DtpA.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..492
FT                   /note="Dipeptide and tripeptide permease A"
FT                   /id="PRO_0000395177"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        44..58
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        80..88
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        110
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        132..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        174..178
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        200..217
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        239..245
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        267..273
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        295..319
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        341..351
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        373..377
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        399..413
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        435..458
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        480..492
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
SQ   SEQUENCE   492 AA;  53594 MW;  A1B44389248204B5 CRC64;
     MSTANKHPEA ASLNAFKQPR SFYLIFSIEL WERFGYYGLQ GIMAVYLVKM LGMSEAQSIT
     LFASFSALVY GLIAVGGWLG DKVLGTKRVI VLGTLVLALG YALVAWSGHD IAMIYFGMAT
     IAVGNGLFKA NPSSLLSTCY EKDDPRLDGA FTMYYMAINI GSFFSMLATP WLAAQFGWST
     AFGLSFVGML ITLVNFMFFR KWVKDHGSKP DFAPLNMGKL LVTLLGIAVM IAAATWLLHN
     QDIARMVLGA VAVAIVVIFT KEALTLKGAA RRKMIVAFLL MLEAIVFFVL YMQMPTSLNF
     FAIRNVEHSL LGIAFQPEQF QALNPFWIMI FSPLLAALYN KLGDRMPMPH KFALGMVLCS
     AAFLVLPLGA SLANKMGIVS VGWLVLSYAL QSVGELMISG LGLAMVAQLV PQRLMGFIMG
     SWFLTTAGAA MVAGKVANLM AVPENITNPL LSLHVYGDIF FKIGITTGVI AVLMILAAPL
     LNRMTQDEQP GV