ID   DTPA_KLEP3              Reviewed;         501 AA.
AC   B5XWP3;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Dipeptide and tripeptide permease A {ECO:0000255|HAMAP-Rule:MF_01878};
GN   Name=dtpA {ECO:0000255|HAMAP-Rule:MF_01878}; OrderedLocusNames=KPK_2376;
OS   Klebsiella pneumoniae (strain 342).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=342;
RX   PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA   Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA   Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA   Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA   Methe B.A.;
RT   "Complete genome sequence of the N2-fixing broad host range endophyte
RT   Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL   PLoS Genet. 4:E1000141-E1000141(2008).
CC   -!- FUNCTION: Proton-dependent permease that transports di- and
CC       tripeptides. {ECO:0000255|HAMAP-Rule:MF_01878}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01878}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01878}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01878}.
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DR   EMBL; CP000964; ACI09792.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5XWP3; -.
DR   SMR; B5XWP3; -.
DR   EnsemblBacteria; ACI09792; ACI09792; KPK_2376.
DR   KEGG; kpe:KPK_2376; -.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; QMMGVWF; -.
DR   OrthoDB; 470322at2; -.
DR   Proteomes; UP000001734; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01878; PTR2_DtpA_subfam; 1.
DR   InterPro; IPR023517; AA/pep_transptr_DtpA.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..501
FT                   /note="Dipeptide and tripeptide permease A"
FT                   /id="PRO_0000395178"
FT   TOPO_DOM        1..21
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        22..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        45..59
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        81..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        111
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        133..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        175..178
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        200..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        240..246
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        268..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        296..320
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        342..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        374..383
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        384..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        405..414
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        436..459
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        481..501
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
SQ   SEQUENCE   501 AA;  54053 MW;  C9B83A3F87C935AD CRC64;
     MSTANNKPAE SVSLNAFKQP RAFYLIFSIE LWERFGYYGL QGIMAVYLVK QLGMSEADSI
     TLFSSFSALV YGLVAIGGWL GDKVLGTKRV IMLGAIVLAI GYALVAWSGH DAAIVYMGMA
     TIAVGNGLFK ANPSSLLSTC YDKNDPRLDG AFTMYYMSIN IGSFFSMLAT PWLAARFGWS
     VAFALSVVGM VITIINFAFC QKWVKQYGSK PDFAPVHMGK LLATIAGVVV LVAIATWLLH
     NQGIARMVLG VVALGIVVIF AKETIGLKGA ARRKMIVAFL LMVEAIVFFV LYSQMPTSLN
     FFAIRNVEHS ILGIAFEPEQ YQALNPFWIM IGSPILAAIY NKMGDRLPMP HKFAIGMVLC
     SGAFLVLPLG AKFASDAGIV SVNWLILSYA LQSIGELMIS GLGLAMVAQL VPQRLMGFIM
     GSWFLTTAGA AIIAGKIANL MAVPENVTDP LVSLEVYGHV FLQIGIVTAV IAALMLLTAP
     KLNRMTQDDS ADLKARETAA A