ID   DTPA_PROMH              Reviewed;         488 AA.
AC   B4EY98;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Dipeptide and tripeptide permease A {ECO:0000255|HAMAP-Rule:MF_01878};
GN   Name=dtpA {ECO:0000255|HAMAP-Rule:MF_01878}; OrderedLocusNames=PMI1584;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- FUNCTION: Proton-dependent permease that transports di- and
CC       tripeptides. {ECO:0000255|HAMAP-Rule:MF_01878}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01878}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01878}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01878}.
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DR   EMBL; AM942759; CAR43316.1; -; Genomic_DNA.
DR   RefSeq; WP_004243443.1; NC_010554.1.
DR   AlphaFoldDB; B4EY98; -.
DR   SMR; B4EY98; -.
DR   STRING; 529507.PMI1584; -.
DR   EnsemblBacteria; CAR43316; CAR43316; PMI1584.
DR   GeneID; 6802870; -.
DR   KEGG; pmr:PMI1584; -.
DR   eggNOG; COG3104; Bacteria.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; QMMGVWF; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01878; PTR2_DtpA_subfam; 1.
DR   InterPro; IPR023517; AA/pep_transptr_DtpA.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..488
FT                   /note="Dipeptide and tripeptide permease A"
FT                   /id="PRO_0000395180"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        57..60
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        82..90
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        112..114
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        136..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        176..179
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        201..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        241
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        263..275
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        297..324
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        346..353
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        375..391
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        413..415
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        437..460
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        482..488
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
SQ   SEQUENCE   488 AA;  53440 MW;  FCB36EA3974B6323 CRC64;
     MSTANTPEDE QKPSLNAFKQ PRAFYLIFSI ELWERFGYYG LQGIMAVYLV KMLGMSEAEA
     ITVFAAFTAL VYGFVAIGGW LGDKILGTKR VIVLGAIVLA IGYAMVAFSD HDKDMIYWGL
     ATIAVGNGLF KANPSSLLAT CYEKDDPQLD GAFTMYYMSI NVGSFLSMLA TPWLAANYGW
     DVAFALSVVG MLITLANFML CRGWIKDKGS RPDFEPLNYL KLLLTLVGIV ALTAVSTWLL
     HNNEVATWSL AIISLGIILI FARETFMMKG VARRKMIVAF LLMVEAVVFF VLYDQMPTSL
     NFFAIHNVEH AILGFSVEPE QFQSLNPFWI MLASPLLAAI YNFMGDKLPM PYKFTVGMFL
     SATAFLVLPL GASMANEAGI VSSWWLVASY GFQSIGELMI SGLGLAMVAQ LVPQRLMGFI
     MGAWFLTSAA AAIIAGKVAS LMAVPEDVQN AHASLEIYSS VFLQIGIVTG VIALLMLFTA
     PMLSKMTQ