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DTPA_SERP5
ID   DTPA_SERP5              Reviewed;         506 AA.
AC   A8GDZ4;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Dipeptide and tripeptide permease A {ECO:0000255|HAMAP-Rule:MF_01878};
GN   Name=dtpA {ECO:0000255|HAMAP-Rule:MF_01878}; OrderedLocusNames=Spro_2233;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-dependent permease that transports di- and
CC       tripeptides. {ECO:0000255|HAMAP-Rule:MF_01878}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01878}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01878}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01878}.
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DR   EMBL; CP000826; ABV41334.1; -; Genomic_DNA.
DR   RefSeq; WP_012144964.1; NC_009832.1.
DR   AlphaFoldDB; A8GDZ4; -.
DR   SMR; A8GDZ4; -.
DR   EnsemblBacteria; ABV41334; ABV41334; Spro_2233.
DR   KEGG; spe:Spro_2233; -.
DR   eggNOG; COG3104; Bacteria.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; QMMGVWF; -.
DR   OrthoDB; 470322at2; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01878; PTR2_DtpA_subfam; 1.
DR   InterPro; IPR023517; AA/pep_transptr_DtpA.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..506
FT                   /note="Dipeptide and tripeptide permease A"
FT                   /id="PRO_0000395181"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        58..61
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        83..91
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        134..155
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        177..180
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        202..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        244..248
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        270..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        298..322
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        344..354
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        376..385
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        407..416
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        438..461
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
FT   TOPO_DOM        483..506
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01878"
SQ   SEQUENCE   506 AA;  55131 MW;  10483AD072D69A92 CRC64;
     MSTANNNSEH PESVSLNAFK QPKAFYLIFS IELWERFGYY GLQGIMAVYL VKMLGLSEAD
     SITLFSSFSA LVYGFVAIGG WLGDKVLGSK RVIVLGALVL AVGYAMVAYS GHEIFWVYLG
     MATIAVGSGL FKANPSSLLS TCYEKDDPRL DGAFTMYYMS VNIGSFLSML ATPWLAAKYG
     WSVAFSLSVV GMLITLVNFM VCHKWVKQHG SKPDFKPLQV KKLLMVLVGV VALVALSSWL
     LHNQIIARWA LAIVSIGIVI VFAKETFALH GAARRKMIVA FLLMLEAVVF FVLYSQMPTS
     LNFFAIHNVE HNILGLAFEP EQYQALNPFW IMLASPILAA LYNKMGDRLP MPHKFAFGMI
     LCSGAFLVLP WGASFANEQG IVSVNWLILS YALQSIGELM ISGLGLAMVA QLVPQRLMGF
     IMGSWFLTTA AAALIAGKVA GLTAVPGDVN DAHASLAIYS HVFMQIGIAT AVIAILMMLT
     APKLHRMTLD TAEDTEKKAQ AAAITN
 
 
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