ID   DTPB_AERHH              Reviewed;         501 AA.
AC   A0KMY1;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Dipeptide and tripeptide permease B {ECO:0000255|HAMAP-Rule:MF_01879};
GN   Name=dtpB {ECO:0000255|HAMAP-Rule:MF_01879}; OrderedLocusNames=AHA_3132;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: Proton-dependent permease that transports di- and
CC       tripeptides. {ECO:0000255|HAMAP-Rule:MF_01879}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01879}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01879}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01879}.
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DR   EMBL; CP000462; ABK36654.1; -; Genomic_DNA.
DR   RefSeq; WP_011706918.1; NC_008570.1.
DR   RefSeq; YP_857632.1; NC_008570.1.
DR   AlphaFoldDB; A0KMY1; -.
DR   SMR; A0KMY1; -.
DR   STRING; 380703.AHA_3132; -.
DR   EnsemblBacteria; ABK36654; ABK36654; AHA_3132.
DR   KEGG; aha:AHA_3132; -.
DR   PATRIC; fig|380703.7.peg.3131; -.
DR   eggNOG; COG3104; Bacteria.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; WNYGFVA; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01879; PTR2_DtpB_subfam; 1.
DR   InterPro; IPR023778; AA/pep_transptr_DtpB.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   PANTHER; PTHR11654:SF102; PTHR11654:SF102; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..501
FT                   /note="Dipeptide and tripeptide permease B"
FT                   /id="PRO_0000395183"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        49..52
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        74..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        104..106
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        128..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        168..172
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        194..211
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        233
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        255..267
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        289..311
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        333..350
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        372..380
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        402..411
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        433..456
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT   TOPO_DOM        478..501
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
SQ   SEQUENCE   501 AA;  55049 MW;  E70CED2957CA8199 CRC64;
     MRPSAPTGLL QQPKPFFMIF FVELWERFGY YGVQGILAVF FVQQLGFSQE QSFITFGAFS
     ALVYGLISVG GYVGDHVLGT KRTMVLGAIV LVIGYFMTGM SIYNPDLIFY ALGTIAVGNC
     LFKANPASLL AKCYERGDPR LDGAFTLFYM SINIGSLISL SLAPVIADHY GYTVTYNLCG
     VGLVIALLTF FACRHMVRDI GSEPDHLPLD YGKLLLVLLG SVALVFFCAW LMHHVVIANM
     VLMTVTLAVV IFFFREAFKL DAVARNKMYV AFVLMLEAVV FYVLYAQMPT SLNFFAINNM
     HHEMLGMSVN PISFQALNPF WVVVGSPVLA MIYTRLGSKG RDLTMPLKFT LGMLFCSLGF
     LTAAASGIWF ADAQGLTSPW FMVLIYLFQS LGELMISALG LAMVAALVPQ RLMGFILGMW
     FLTQAMASLL GGYVATFTAV PQGVTDPLQT LPIYTDVFGK IGLVTLLVAV VMALMVPWLN
     RMMHAGQGEE GEDLLSQQAK A