DTPB_PHOAA
ID DTPB_PHOAA Reviewed; 489 AA.
AC B6VMU9; C7BNI8;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Dipeptide and tripeptide permease B {ECO:0000255|HAMAP-Rule:MF_01879};
GN Name=dtpB {ECO:0000255|HAMAP-Rule:MF_01879}; OrderedLocusNames=PAU_00908;
GN ORFNames=PA-RVA14-1103;
OS Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
OS (Xenorhabdus luminescens (strain 2)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=553480;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=18838673; DOI=10.1073/pnas.0711114105;
RA Waterfield N.R., Sanchez-Contreras M., Eleftherianos I., Dowling A.,
RA Yang G., Wilkinson P., Parkhill J., Thomson N., Reynolds S.E., Bode H.B.,
RA Dorus S., Ffrench-Constant R.H.;
RT "Rapid virulence annotation (RVA): identification of virulence factors
RT using a bacterial genome library and multiple invertebrate hosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:15967-15972(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43949 / 3105-77;
RX PubMed=19583835; DOI=10.1186/1471-2164-10-302;
RA Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
RA Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
RA Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C.,
RA Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.;
RT "Comparative genomics of the emerging human pathogen Photorhabdus
RT asymbiotica with the insect pathogen Photorhabdus luminescens.";
RL BMC Genomics 10:302-302(2009).
CC -!- FUNCTION: Proton-dependent permease that transports di- and
CC tripeptides. {ECO:0000255|HAMAP-Rule:MF_01879}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01879}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01879}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01879}.
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DR EMBL; FM211056; CAR67479.1; -; Genomic_DNA.
DR EMBL; FM162591; CAQ83000.1; -; Genomic_DNA.
DR AlphaFoldDB; B6VMU9; -.
DR SMR; B6VMU9; -.
DR EnsemblBacteria; CAQ83000; CAQ83000; PAU_00908.
DR KEGG; pay:PAU_00908; -.
DR eggNOG; COG3104; Bacteria.
DR OMA; WNYGFVA; -.
DR Proteomes; UP000002747; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01879; PTR2_DtpB_subfam; 1.
DR InterPro; IPR023778; AA/pep_transptr_DtpB.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR PANTHER; PTHR11654:SF102; PTHR11654:SF102; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS01022; PTR2_1; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..489
FT /note="Dipeptide and tripeptide permease B"
FT /id="PRO_0000395185"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 49..52
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 74..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 104..106
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 128..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 168..171
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 193..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 255..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 289..311
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 333..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 372..375
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 397..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 441..456
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 478..489
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
SQ SEQUENCE 489 AA; 53837 MW; 4B4CAB25328B45F8 CRC64;
MNKPASIGLL QQPKPFFMIF FVELWERFGY YGVQGILAVY FVHKLGFSQE QAFTTFGAFA
ALVYGLIAIG GYVGDHLLGT KRTIVLGAIV LTVGYFMTGL SILKPELIFY ALGTIAVGNG
LFKANPASLL SKCYPPKDPR LDGAFTLFYM SINIGSLFSL AIAPVIAEKF GYAVTYNICG
IGLIIALLVY VLYRNTVRNI GSEPDHRPIN YKNLLLVLAG TVTMVFVCAW LMHNVKIANI
VLIGLSVVIV FIFFREAFKQ DKVGRNKMFV AFILMLQAIV FFILYAQMPT SLNFFAINNV
HHQLLGFNIN PVSFQALNPF WIVVASPILA ALYTHWGSRS KDLTMPAKFT VGMFLCSLGF
LTAAAAGLWF ADEQGLTSPW FIVLVYLFQS LGELMISALG LAMVAALVPQ YLMGFILGMW
YLTQATSFLL GGYVAAFTAI PEGITDPLET LPVYTNVFGK IGITTFIVAI IMAITVPLLN
RMMNGKQKA
