DTPB_SALTY
ID DTPB_SALTY Reviewed; 489 AA.
AC Q8ZLD6;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Dipeptide and tripeptide permease B {ECO:0000255|HAMAP-Rule:MF_01879};
GN Name=dtpB {ECO:0000255|HAMAP-Rule:MF_01879}; OrderedLocusNames=STM3592;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Proton-dependent permease that transports di- and
CC tripeptides. {ECO:0000255|HAMAP-Rule:MF_01879}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01879}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01879}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01879}.
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DR EMBL; AE006468; AAL22452.1; -; Genomic_DNA.
DR RefSeq; NP_462493.1; NC_003197.2.
DR RefSeq; WP_001098277.1; NC_003197.2.
DR AlphaFoldDB; Q8ZLD6; -.
DR SMR; Q8ZLD6; -.
DR STRING; 99287.STM3592; -.
DR PaxDb; Q8ZLD6; -.
DR EnsemblBacteria; AAL22452; AAL22452; STM3592.
DR GeneID; 1255115; -.
DR KEGG; stm:STM3592; -.
DR PATRIC; fig|99287.12.peg.3796; -.
DR HOGENOM; CLU_004790_0_0_6; -.
DR PhylomeDB; Q8ZLD6; -.
DR BioCyc; SENT99287:STM3592-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015333; F:peptide:proton symporter activity; IBA:GO_Central.
DR GO; GO:0042937; F:tripeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd17346; MFS_DtpA_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01879; PTR2_DtpB_subfam; 1.
DR InterPro; IPR023778; AA/pep_transptr_DtpB.
DR InterPro; IPR005279; Dipep/tripep_permease.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR PANTHER; PTHR11654:SF102; PTHR11654:SF102; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR PROSITE; PS01023; PTR2_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..489
FT /note="Dipeptide and tripeptide permease B"
FT /id="PRO_0000395187"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 49..52
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 74..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 104..106
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 128..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 168..172
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 194..214
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 236
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 258..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 289..315
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 339..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 370..379
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 401..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 432..454
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
FT TOPO_DOM 476..489
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01879"
SQ SEQUENCE 489 AA; 53599 MW; 59B36132E3642619 CRC64;
MNTTAPTGLL QQPRPFFMIF FVELWERFGY YGVQGILAVF FVKQLGFSQE QAFITFGAFA
ALVYGLISIG GYVGDHLLGT KRTLVLGAIV LAIGYFMTGM SLLNPDLIFI ALGTIAVGNG
LFKANPASLL SKCYQPKDPR LDGAFTLFYM SINIGSLLSL SLAPVIADKF GYAVTYNLCG
AGLIVALLVY FACRGMVKNI GSEPDHKPLR FRNLLLVLLG TVVMIFLCAW LMHNVKIANL
VLIVLSIVVT IFFFREAFRL DKTGRNKMFV AFILMIEAVL FYILYAQMPT SLNFFAINNV
HHEILGFAIN PVSFQALNPF WVVVASPVLA AIYTRLGSKG KDLTMPMKFT LGMFLCALGF
LTAAAGMWFA DAQGLTSPWF IVLVYLFQSL GELLISALGL AMVAALVPQH LMGFILGMWF
LTQAAAFLLG GYVATFTAVP ENITDPLQTL PIYTGVFSKI GLVTLAVTVV MAIMVPWLNR
MINTPGTEQ
