ID   DTPD_CITK8              Reviewed;         493 AA.
AC   A8AJB3;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN   Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880}; OrderedLocusNames=CKO_02459;
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable proton-dependent permease that transports
CC       dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01880}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR   EMBL; CP000822; ABV13576.1; -; Genomic_DNA.
DR   RefSeq; WP_012133300.1; NC_009792.1.
DR   AlphaFoldDB; A8AJB3; -.
DR   SMR; A8AJB3; -.
DR   STRING; 290338.CKO_02459; -.
DR   EnsemblBacteria; ABV13576; ABV13576; CKO_02459.
DR   GeneID; 45136348; -.
DR   KEGG; cko:CKO_02459; -.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; GMMMGLW; -.
DR   OrthoDB; 470322at2; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR   InterPro; IPR023777; AA/pep_transptr_DtpD.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..493
FT                   /note="Dipeptide permease D"
FT                   /id="PRO_0000395293"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ   SEQUENCE   493 AA;  53904 MW;  D5105C77AB0AA87D CRC64;
     MNKPSSQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDNHAYAL FSAYCSLVYV
     TPILGGYLAD KVLGNRMAVM LGAFLMAVGH LVLGASEIAP TFLYLSLAII VCGYGLFKSN
     ISCLLGELYK PEDPRRDGGF SLLYAAGNIG SIVAPIACGY VQEEYSWAMG FALAAIGMIA
     GLIIFLCGNR HFAHTTGVNK AALHARTFVL PNWCWLLVLL VAAPLLITVL FWKEWSVYAL
     IVATVIGLAV LTKIYRQAQT QKQRKELGLI VVLTFFSMLF WAFAQQGGSS ISLYIDRFVN
     RTILGYEVPT AMFQSVNAFA VMLCGVVLAW LIKESMGGNR TVRIWGKFAL GLGLMSAGFC
     ILTVSARLSA AYGHSSMPLM ILGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML
     LSGAIANYLA GVIADQTSQS AFDASGAINY AINAYIDVFD QITWGALACV ALVLLIWLYQ
     SLKFRNRPLA VES