ID   DTPD_CITRI              Reviewed;         493 AA.
AC   D2TNL4;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Dipeptide permease D {ECO:0000255|HAMAP-Rule:MF_01880};
GN   Name=dtpD {ECO:0000255|HAMAP-Rule:MF_01880}; OrderedLocusNames=ROD_07091;
OS   Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=637910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC168;
RX   PubMed=19897651; DOI=10.1128/jb.01144-09;
RA   Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA   Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA   Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT   "The Citrobacter rodentium genome sequence reveals convergent evolution
RT   with human pathogenic Escherichia coli.";
RL   J. Bacteriol. 192:525-538(2010).
CC   -!- FUNCTION: Probable proton-dependent permease that transports
CC       dipeptides. {ECO:0000255|HAMAP-Rule:MF_01880}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01880}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01880}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01880}.
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DR   EMBL; FN543502; CBG87484.1; -; Genomic_DNA.
DR   RefSeq; WP_012905038.1; NC_013716.1.
DR   AlphaFoldDB; D2TNL4; -.
DR   SMR; D2TNL4; -.
DR   KEGG; cro:ROD_07091; -.
DR   eggNOG; COG3104; Bacteria.
DR   HOGENOM; CLU_004790_0_0_6; -.
DR   OMA; GMMMGLW; -.
DR   OrthoDB; 470322at2; -.
DR   Proteomes; UP000001889; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015333; F:peptide:proton symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd17346; MFS_DtpA_like; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01880; PTR2_DtpD_subfam; 1.
DR   InterPro; IPR023777; AA/pep_transptr_DtpD.
DR   InterPro; IPR005279; Dipep/tripep_permease.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00924; yjdL_sub1_fam; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
DR   PROSITE; PS01023; PTR2_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Peptide transport;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..493
FT                   /note="Dipeptide permease D"
FT                   /id="PRO_0000395294"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01880"
SQ   SEQUENCE   493 AA;  53687 MW;  572E8A9BE9DA7752 CRC64;
     MKKASSQPRA IYYVVALQIW EYFSFYGMRA LLILYLTNQL KYDDTHAYAL FSAYCSLVYV
     TPILGGYLAD KVLGNRMAVM LGAFLMAVGH LVLGASEIAP TFLYLSLAII VCGYGLFKSN
     ISCLLGELYQ TEDPRRDGGF SLLYAAGNVG SIVAPIACGY VQEEYSWAMG FALAAIGMVA
     GLIIFLCGNR HFTHTKGVNK AALCARSFIL PNWGWLLVLL TIAPLAIAVL FWQEWAVYAL
     IVATAIGLAV LGKIYRQAEN QKQRKELGLI VTLTFFSMLF WAFAQQGGSS ISLYIDRFVN
     RHIFGYSVPT AMFQSVNAFA VMLCGVVLAW LIKESIGGNR SVRIWGKFAL GLGLMSAGFS
     ILTLSARWSA AYGHSSMPLM IAGLAVMGFA ELFIDPVAMS QITRIEIPGV TGVLTGIYML
     LSGAIANYLA GVIADRTSQS AFDASGAINY SINAYIDVFS EITWGALACV GLVLLIWLYQ
     SLKFRNRPLA VGS